is involved in developmental speech and language disorders and directly regulates targets related to neural development and synaptic plasticity and developmental disorders like autism and schizophrenia (Vernes et al. 2007, 2008). In addition, the gene showed association in GWAS of schizophrenia (Sullivan et al. 2008) at P = 10−5 and of bipolar disorder (Sklar et al. 2008) at P = 10−4 rs2290416Additive8.51E-068144728743In coding exon of NAPRT1Encodes nicotinate phosphoribosyltransferase domain containing 1, which is part of an enzymatic pathway that leads to production of nicotinamide adenine dinucleotide (NAD) from niacin (nicotinic acid), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress. Expression in many tissues including brainSite known for CNVsrs10767942Dominant7.90E-061132478583IntergenicThe finding lies within/near linkage regions for autism (Duvall et al. 2007; Szatmari et al. 2007b; Trikalinos et al. 2006)rs7992643Dominant5.45E-061399353039Within 15 kb downstream of CLYBLEncodes citrate lyase beta like protein of unknown function. Expression in many tissues including brain. The finding lies within/near linkage regions for bipolar disorder (Detera-Wadleigh et al. 1999) and schizophrenia (Blouin et al. 1998)Hyperactive-impulsive symptom countrs11590090Recessive2.51E-061113115086Within 60 kb downstream of FAM19A3Encodes ‘family with sequence similarity 19 [chemokine (C–C motif)-like], member A3’.
