brain. The finding lies within a linkage region for schizophrenia observed in meta-analysis (Lewis et al. 2003) and a recent primary study (Irmansyah et al. 2008). The gene showed association in GWAS of bipolar disorder (Wellcome Trust Case Control Consortium 2007) at P values of 10−5 Site known for CNVsrs6791644Recessive8.32E-06360746148In intron of FHITEncodes a diadenosine 5′,5′′′-P1,P3-triphosphate hydrolase involved in purine metabolism. FHIT has a major role in regulating beta-catenin-mediated gene transcription. Expression in many tissues including brain. Gene is also found among top-findings from GWAS in schizophrenia (Sullivan et al. 2008) and is affected by CNVs in autism (Marshall et al. 2008; Sebat et al. 2007)rs17651978Recessive6.05E-06371103180In intron or 5′ UTR of FOXP1Encodes Forkhead box protein P1, which belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. The gene shows universal expression. FOXP2, another family member is involved in developmental speech and language disorders and directly regulates targets related to neural development and synaptic plasticity and developmental disorders like autism and schizophrenia (Vernes et al. 2007, 2008). In addition, the gene showed association in GWAS of
