Odds ratios for the susceptibility allele for the ten independent type 1 diabetes associated genes or regions. The filled black bars indicate previously known associated genes and regions. The open bar indicates the IFIH1 region identified by the nsSNP genome scan2 (Table 2), and the filled gray bars were identified by the WTCCC Affymetrix 500K scan1 and confirmed by the studies reported here (Table 1). The HLA class II SNP (rs3129934) was the marker with the highest association with T1D in the MHC 25-35 Mb region in the WTCCC study1.
