Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
paper
Cited
Public
- Authors
- Todd, John A; Walker, Neil M; Cooper, Jason D; Smyth, Deborah J; Downes, Kate; Plagnol, Vincent; Bailey, Rebecca; Nejentsev, Sergey; Field, Sarah F; Payne, Felicity; Lowe, Christopher E; Szeszko, Jeffrey S; Hafler, Jason P; Zeitels, Lauren; Yang, Jennie H M; Vella, Adrian; Nutland, Sarah; Stevens, Helen E; Schuilenburg, Helen; Coleman, Gillian; Maisuria, Meeta; Meadows, William; Smink, Luc J; Healy, Barry; Burren, Oliver S; Lam, Alex A C; Ovington, Nigel R; Allen, James; Adlem, Ellen; Leung, Hin-Tak; Wallace, Chris; Howson, Joanna M M; Guja, Cristian; Ionescu-Tรฎrgoviลte, Constantin; Genetics of Type 1 Diabetes in Finland; Simmonds, Matthew J; Heward, Joanne M; Gough, Stephen C L; Wellcome Trust Case Control Consortium; Dunger, David B; Wicker, Linda S; Clayton, David G
- Year
- 2007
- Journal
- Nature genetics
- PMID
- 17554260
- DOI
- 10.1038/ng2068
- PMCID
- PMC2492393
The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) <or= 1.35 x 10(-9); P(overall) <or= 1.15 x 10(-14)), leaving eight regions with small effects or false-positive associations. We also obtained evidence for chromosome 18q22 (P(overall) = 1.38 x 10(-8)) from a GWA study of nonsynonymous SNPs. Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten.
Odds ratios for the susceptibility allele for the ten independent type 1 diabetes associated genes or regions. The filled black bars indicate previously known associated genes and regions. The open bar indicates the IFIH1 region identified by the nsSNP genome scan2 (Table 2), and the filled gray bars were identified by the WTCCC Affymetrix 500K scan1 and confirmed by the studies reported here (Table 1). The HLA class II SNP (rs3129934) was the marker with the highest association with T1D in the MHC 25-35 Mb region in the WTCCC study1.
1โ19 of 19
| Name | Type |
|---|---|
| 32 individuals with T1D local | cohort |
| affected sib pairs local | cohort |
| AITD UK National Collection local | cohort |
| allele frequency differences local | phenotype |
| Applied Biosystems | drug |
| Biochemical hyperthyroidism local | phenotype |
| British 1958 Birth Cohort local | cohort |
| case cohort | cohort |
| case/control status | phenotype |
| cases | cohort |
| case subjects | cohort |
| CEPH DNA samples (Utah residents with northern and western European ancestry) local | cohort |
| control | cohort |
| controls | cohort |
| DEXI local | gene |
| Diffuse goiter local | phenotype |
| families | cohort |
| Finnish families local | cohort |
| Graves' disease | phenotype |
| HLA | gene |
| HLA class II loci local | gene |
| IFIH1 | gene |
| IL2 local | gene |
| IL21 local | gene |
| JDRF/WT British case collection (Genetic Resource Investigating Diabetes) local | cohort |
| Juvenile Diabetes local | phenotype |
| KIAA0350 local | gene |
| MHC2TA local | gene |
| Northern Ireland families local | cohort |
| Norwegian families local | cohort |
| NRP1 local | gene |
| nsSNP | variant |
| nsSNP study local | cohort |
| PTPN2 local | gene |
| Romanian families local | cohort |
| rs1893217 local | variant |
| rs2666236 local | variant |
| rs3129934 local | variant |
| rs478582 local | variant |
| SNP | cohort |
| SOCS1 | gene |
| TaqMan genotyping local | drug |
| Tenr local | gene |
| Thyroglobulin autoantibodies local | drug |
| Thyroid eye disease local | phenotype |
| Thyroid peroxidase autoantibodies local | drug |
| TLR region local | gene |
| TSHR autoantibodies local | drug |
| type 1 diabetes | phenotype |
| UK Diabetes UK Warren 1 repository local | cohort |
| USA Human Biological Data Interchange local | cohort |
| WTCCC | cohort |
| Yorkshire, UK families local | cohort |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases. | Tiganis T et al. | โ | 2026 | โ |
| A Bibliometric Analysis of GWAS on Rheumatoid Arthritis from 2002 to 2024. | Wang WH et al. | โ | 2025 | โ |
| Advances in the Pathogenesis and Treatment Strategies for Type 1 Diabetes Mellitus. | Du M et al. | โ | 2025 | โ |
| Association of IL2RA and multiple sclerosis risk: A case control, systematic review, and meta-analysis study. | Rangani F et al. | โ | 2025 | โ |
| Association of the Immunity Genes with Type 1 Diabetes Mellitus. | Khaiz Y et al. | โ | 2025 | โ |
| Autoimmune diabetes and targets for immunomodulation. | Bechi Genzano C et al. | โ | 2025 | โ |
| Autoimmune thyroid disease and pituitary adenoma in a female patient with 18p deletion syndrome: a case report and review of the literature. | Ye J et al. | โ | 2025 | โ |
| Challenges and Opportunities for Understanding the Pathogenesis of Type 1 Diabetes: An Endocrine Society Scientific Statement. | Michels AW et al. | โ | 2025 | โ |
| Complement at the crossroads of inflammation and metabolism: implications for diabetes and metabolic functions. | Dandavate V et al. | โ | 2025 | โ |
| Deletion of Ptpn2 in B cells promotes autoimmunity via TLR and JAK/STAT signaling. | Alexander BN et al. | โ | 2025 | โ |
| Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms. | Wang F et al. | โ | 2025 | โ |
| Glucose Extremes and Cognitive Function: A Review of the Neurological Impacts of Hypoglycemia and Hyperglycemia in Type 1 Diabetes. | Davis DA et al. | โ | 2025 | โ |
| Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset. | Golden GJ et al. | โ | 2025 | โ |
| Interactions between islet-resident macrophages and ฮฒ cells in diabetes. | Zhang D et al. | โ | 2025 | โ |
| Interplay between the host genome, autoimmune disease and infection. | San-Martรญn MI et al. | โ | 2025 | โ |
| Linking epigenetic mechanisms of T cell dysfunction with pathophysiology of type 1 diabetes mellitus. | Jabri A et al. | โ | 2025 | โ |
| Lnk/Sh2b3 regulates initiation and severity of autoimmune insulitis and contributes to diabetes risk. | Tenno M et al. | โ | 2025 | โ |
| Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancer. | Kuang J et al. | โ | 2025 | โ |
| Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes. | Jumentier B et al. | โ | 2025 | โ |
| Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226<sup>+</sup> B cells in type 1 diabetes. | Li J et al. | โ | 2025 | โ |
| Neutralizing the IL-7Rฮฑ limits injury in experimental ANCA-associated glomerulonephritis. | Alikhan MA et al. | โ | 2025 | โ |
| Protein phosphatases in systemic autoimmunity. | Pan W et al. | โ | 2025 | โ |
| Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics. | Bennett AM et al. | โ | 2025 | โ |
| PTPN2: Advances and perspectives in cancer treatment potential and inhibitor research. | Zhang Y et al. | โ | 2025 | โ |
| Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance. | Watson TK et al. | โ | 2025 | โ |
| Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential. | Wang L et al. | โ | 2025 | โ |
| The immunological landscape of primary biliary cholangitis: Mechanisms and therapeutic prospects. | Ronca V et al. | โ | 2025 | โ |
| Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene. | Spalinger MR et al. | โ | 2025 | โ |
| Transcriptomic characterization of human pancreatic CD206- and CD206โ+โmacrophages. | Jonsson A et al. | โ | 2025 | โ |
| Type 1 Diabetes Genetics Consortium. | Onengut-Gumuscu S et al. | โ | 2025 | โ |
| Advancing Animal Models of Human Type 1 Diabetes. | Serreze DV et al. | โ | 2024 | โ |
| A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis. | Hitomi Y et al. | โ | 2024 | โ |
| Association of RPS26 gene polymorphism with different types of diabetes in Chinese individuals. | Song R et al. | โ | 2024 | โ |
| Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity. | Sakano Y et al. | โ | 2024 | โ |
| Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment. | Yau C et al. | โ | 2024 | โ |
| Exploring noncoding variants in genetic diseases: from detection to functional insights. | Wu K et al. | โ | 2024 | โ |
| Gene-environment interaction in the pathophysiology of type 1 diabetes. | Mittal R et al. | โ | 2024 | โ |
| Genetics of type-1 diabetes. | Ikegami H et al. | โ | 2024 | โ |
| Genetic Variant of DNAM-1 rs763361 C>T Is Associated with Ankylosing Spondylitis in a Mexican Population. | Vรกzquez-Reyes A et al. | โ | 2024 | โ |
| Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus. | Jeanpierre M et al. | โ | 2024 | โ |
| Identification of a prognostic signature based on five ferroptosis-related genes for diffuse large B-cell lymphoma. | Li W et al. | โ | 2024 | โ |
| Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes. | Fogarasi M et al. | โ | 2024 | โ |
| Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP. | Perez-Quintero LA et al. | โ | 2024 | โ |
| Importance of Studying Non-Coding RNA in Children and Adolescents with Type 1 Diabetes. | Cabiati M et al. | โ | 2024 | โ |
| Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on <i>FOXP3</i> introns. | Nagasawa CK et al. | โ | 2024 | โ |
| Interleukin-27 and Autoimmune Disorders: A Compressive Review of Immunological Functions. | Yazdanpanah E et al. | โ | 2024 | โ |
| Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases. | Fu Y et al. | โ | 2024 | โ |
| NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation. | Caron L et al. | โ | 2024 | โ |
| Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases. | Borysewicz-Saลczyk H et al. | โ | 2024 | โ |
| PTPN2 Regulates Metabolic Flux to Affect ฮฒ-Cell Susceptibility to Inflammatory Stress. | Kim YK et al. | โ | 2024 | โ |
| Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis inย vitro and inย vivo. | Nemkov T et al. | โ | 2024 | โ |
| Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2. | Jo Y et al. | โ | 2024 | โ |
| Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies. | Salmond RJ | โ | 2024 | โ |
| Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both? | Hardtke-Wolenski M et al. | โ | 2024 | โ |
| Viral infection and host immune response in diabetes. | Joshi G et al. | โ | 2024 | โ |
| A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. | Liang S et al. | โ | 2023 | โ |
| Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in the <i>IFIH1</i> gene with susceptibility to autoimmune diseases: a meta-analysis. | Xiao Z et al. | โ | 2023 | โ |
| Autoimmunity in Primary Immunodeficiencies (PID). | Padron GT et al. | โ | 2023 | โ |
| Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population. | Liao WL et al. | โ | 2023 | โ |
| DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis. | Zhang Z et al. | โ | 2023 | โ |
| Genetic and epigenetic background of diabetic kidney disease. | Sandholm N et al. | โ | 2023 | โ |
| Genetic improvement of economic traits in Murrah buffalo using significant SNPs from genome-wide association study. | George L et al. | โ | 2023 | โ |
| Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the "omnigenic" sparse effector hypothesis of complex trait genetics. | Iakovliev A et al. | โ | 2023 | โ |
| Germline mechanisms of immunotherapy toxicities in the era of genome-wide association studies. | Gusev A | โ | 2023 | โ |
| Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. | Sacks DB et al. | โ | 2023 | โ |
| Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. | Sacks DB et al. | โ | 2023 | โ |
| <i>CLEC16A</i>-An Emerging Master Regulator of Autoimmunity and Neurodegeneration. | Pandey R et al. | โ | 2023 | โ |
| Identification of gene mutations associated with type 1 diabetes by next-generation sequencing in affected Palestinian families. | Bawatneh A et al. | โ | 2023 | โ |
| IL-2-based approaches to Treg enhancement. | Harris F et al. | โ | 2023 | โ |
| <i>PTPN22</i> R620W gene editing in T cells enhances low-avidity TCR responses. | Anderson W et al. | โ | 2023 | โ |
| Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk | Simeonov DR et al. | โ | 2023 | โ |
| PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection. | Spalinger MR et al. | โ | 2023 | โ |
| Regulatory T cells in autoimmune kidney diseases and transplantation. | Mikami N et al. | โ | 2023 | โ |
| SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis. | Pandey R et al. | โ | 2023 | โ |
| Activation pathways that drive CD4<sup>+</sup> T cells to break tolerance in autoimmune diseases. | Krovi SH et al. | โ | 2022 | โ |
| Altered islet prohormone processing: a cause or consequence of diabetes? | Ramzy A et al. | โ | 2022 | โ |
| Arid1a loss potentiates pancreatic ฮฒ-cell regeneration through activation of EGF signaling. | Celen C et al. | โ | 2022 | โ |
| A Role for lncRNAs in Regulating Inflammatory and Autoimmune Responses Underlying Type 1 Diabetes. | Brodnicki TC | โ | 2022 | โ |
| Autoimmune susceptibility gene <i>PTPN2</i> is required for clearance of adherent-invasive <i>Escherichia coli</i> by integrating bacterial uptake and lysosomal defence. | Spalinger MR et al. | โ | 2022 | โ |
| Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis. | Elsherbini AM et al. | โ | 2022 | โ |
| Diabetes and Its Cardiovascular Complications: Comprehensive Network and Systematic Analyses. | Wu H et al. | โ | 2022 | โ |
| Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes. | Gootjes C et al. | โ | 2022 | โ |
| Functional interrogation of autoimmune disease genetics using CRISPR/Cas9 technologies and massively parallel reporter assays. | Ding J et al. | โ | 2022 | โ |
| G307S DNAM-1 Mutation Exacerbates Autoimmune Encephalomyelitis via Enhancing CD4<sup>+</sup> T Cell Activation. | Murata R et al. | โ | 2022 | โ |
| GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing. | Mathur R et al. | โ | 2022 | โ |
| Genetic Modifiers of Thymic Selection and Central Tolerance in Type 1 Diabetes. | Kissler S | โ | 2022 | โ |
| Genetic overlap between type 1 diabetes and other autoimmune diseases. | Mรกrquez A et al. | โ | 2022 | โ |
| HLA-DRB1 and -DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations. | Al Yafei Z et al. | โ | 2022 | โ |
| IL-7: Comprehensive review. | Winer H et al. | โ | 2022 | โ |
| IL-7/IL7R axis dysfunction in adults with severe community-acquired pneumonia (CAP): a cross-sectional study. | Ampuero S et al. | โ | 2022 | โ |
| Immune dysregulation associated with co-occurring germline CBL and SH2B3 variants. | Baccelli F et al. | โ | 2022 | โ |
| Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjรถgren's syndrome. | Keindl M et al. | โ | 2022 | โ |
| In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size. | Shyamala N et al. | โ | 2022 | โ |
| Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features. | Hoffmann M et al. | โ | 2022 | โ |
| ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents. | Libman I et al. | โ | 2022 | โ |
| Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors. | Kremer J et al. | โ | 2022 | โ |
| Pathogenic Mechanism of Autoimmune Diabetes Mellitus in Humans: Potential Role of Streptozotocin-Induced Selective Autoimmunity against Human Islet <i>ฮฒ</i>-Cells. | Zhu BT | โ | 2022 | โ |
| PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review. | Song J et al. | โ | 2022 | โ |
| The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes. | Rojas M et al. | โ | 2022 | โ |
| The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy. | Wang C et al. | โ | 2022 | โ |
| Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study. | Smyth LJ et al. | โ | 2021 | โ |
| Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score. | Qu J et al. | โ | 2021 | โ |
| Association of <i>AFF3</i> Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort. | Ali Y et al. | โ | 2021 | โ |
| Association of vitamin D receptor gene polymorphism with type 1 diabetes mellitus risk in children: A protocol for systematic review and meta-analysis. | Ran Y et al. | โ | 2021 | โ |
| Diabetes and Genetics: A Relationship Between Genetic Risk Alleles, Clinical Phenotypes and Therapeutic Approaches. | Sayed S et al. | โ | 2021 | โ |
| Epidemiology and genetics of granulomatosis with polyangiitis. | Banerjee P et al. | โ | 2021 | โ |
| EPISPOT: An epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies. | Ruffieux H et al. | โ | 2021 | โ |
| Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells. | Eriksson AM et al. | โ | 2021 | โ |
| Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. | Robertson CC et al. | โ | 2021 | โ |
| Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes. | Bettini M et al. | โ | 2021 | โ |
| Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn's Disease: On the Way to Personalized Medicine? | Hoffmann P et al. | โ | 2021 | โ |
| Genetic aspects of adult and pediatric autoimmune hepatitis: A concise review. | Engel B et al. | โ | 2021 | โ |
| Genome-wide search for genes affecting the age at diagnosis of type 1 diabetes. | Syreeni A et al. | โ | 2021 | โ |
| Human CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocyte subpopulations have significantly different surface expression patterns of CD226 and TIGIT molecules. | ล unina M et al. | โ | 2021 | โ |
| <i>Alu</i> insertion variants alter gene transcript levels. | Payer LM et al. | โ | 2021 | โ |
| Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome. | Lee JH et al. | โ | 2021 | โ |
| Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes. | Cerqueira JXM et al. | โ | 2021 | โ |
| Influence of <i>PTPN22</i> Allotypes on Innate and Adaptive Immune Function in Health and Disease. | Armitage LH et al. | โ | 2021 | โ |
| Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes. | Hehenkamp P et al. | โ | 2021 | โ |
| JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice. | Pandey R et al. | โ | 2021 | โ |
| Knockdown of NAA25 Suppresses Breast Cancer Progression by Regulating Apoptosis and Cell Cycle. | Xu J et al. | โ | 2021 | โ |
| lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response. | Plasek LM et al. | โ | 2021 | โ |
| Long non-coding RNA-regulated pathways in pancreatic ฮฒ cells: Their role in diabetes. | Gonzรกlez-Moro I et al. | โ | 2021 | โ |
| Long, Noncoding RNA SRA Induces Apoptosis of ฮฒ-Cells by Promoting the IRAK1/LDHA/Lactate Pathway. | Huang YN et al. | โ | 2021 | โ |
| Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N<sub>2</sub> in Dendritic Cells to Protect from Elevated Colitis. | Hering L et al. | โ | 2021 | โ |
| Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis. | Denoth L et al. | โ | 2021 | โ |
| Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers. | Simoes JP et al. | โ | 2021 | โ |
| Multi-tissue transcriptome-wide association studies. | Grinberg NF et al. | โ | 2021 | โ |
| Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden. | Zhao LP et al. | โ | 2021 | โ |
| Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas. | Parv K et al. | โ | 2021 | โ |
| Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis. | Kawai VK et al. | โ | 2021 | โ |
| Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin. | Hochheiser K et al. | โ | 2021 | โ |
| Self-Renewing Islet TCF1<sup>+</sup> CD8 T Cells Undergo IL-27-Controlled Differentiation to Become TCF1<sup>-</sup> Terminal Effectors during the Progression of Type 1 Diabetes. | Ciecko AE et al. | โ | 2021 | โ |
| Soluble IL-7Rฮฑ/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic Agent. | Barros PO et al. | โ | 2021 | โ |
| The ฮฒ-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis. | Ramos-Rodrรญguez M et al. | โ | 2021 | โ |
| Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells. | Conde J et al. | โ | 2021 | โ |
| Transcriptomic Analysis of Peripheral Monocytes upon Fingolimod Treatment in Relapsing Remitting Multiple Sclerosis Patients. | Sferruzza G et al. | โ | 2021 | โ |
| Type I interferons as key players in pancreatic ฮฒ-cell dysfunction in type 1 diabetes. | Marroqui L et al. | โ | 2021 | โ |
| U2AF2 binds <i>IL7R</i> exon 6 ectopically and represses its inclusion. | Schott G et al. | โ | 2021 | โ |
| Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes. | Armitage LH et al. | โ | 2021 | โ |
| ฮฒ-cell self-destruction and extremely complicated and still unknown etiopathogenesis of type 1 diabetes. | Chwalba A et al. | โ | 2021 | โ |
| Association of HLA-DRB1 and -DQ Alleles and Haplotypes with Type 1 Diabetes in Jordanians. | Khdair SI et al. | โ | 2020 | โ |
| CD226: An Emerging Role in Immunologic Diseases. | Huang Z et al. | โ | 2020 | โ |
| CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. | Shapiro MR et al. | โ | 2020 | โ |
| Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI. | Gingerich MA et al. | โ | 2020 | โ |
| Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes. | Claessens LA et al. | โ | 2020 | โ |
| Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8<sup>+</sup> T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy. | Weulersse M et al. | โ | 2020 | โ |
| Epigenetic modification and therapeutic targets of diabetes mellitus. | Singh R et al. | โ | 2020 | โ |
| Exploring the Triple Interaction between the Host Genome, the Epigenome, and the Gut Microbiome in Type 1 Diabetes. | Elhag DA et al. | โ | 2020 | โ |
| Failed Genetic Protection: Type 1 Diabetes in the Presence of <i>HLA-DQB1*06:02</i>. | Simmons KM et al. | โ | 2020 | โ |
| Find the Needle in the Haystack, Then Find It Again: Replication and Validation in the 'Omics Era. | Perng W et al. | โ | 2020 | โ |
| Functional genomics in autoimmune diseases. | Ding J et al. | โ | 2020 | โ |
| Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk. | Xia Z et al. | โ | 2020 | โ |
| Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes. | Borysewicz-Saลczyk H et al. | โ | 2020 | โ |
| Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease. | Miele L et al. | โ | 2020 | โ |
| IL7RA genetic variants differentially affect IL-7Rฮฑ expression and alternative splicing: a role in autoimmune and infectious diseases? | Lundtoft C et al. | โ | 2020 | โ |
| Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With <i>IL2RA</i> and <i>PTPN2</i> Gene Polymorphisms. | Keindl M et al. | โ | 2020 | โ |
| Influence of <i>SH2B3</i>, <i>MTHFD1L</i>, <i>GGCX</i>, and <i>ITGB3</i> Gene Polymorphisms on theVariability on Warfarin Dosage Requirements and Susceptibility to CVD in the Jordanian Population. | Al-Eitan LN et al. | โ | 2020 | โ |
| Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial. | Marcovecchio ML et al. | โ | 2020 | โ |
| It Takes Three Receptors to Raise a B Cell. | McLean KC et al. | โ | 2020 | โ |
| Long Non-Coding RNAs as Key Modulators of Pancreatic ฮฒ-Cell Mass and Function. | Lรณpez-Noriega L et al. | โ | 2020 | โ |
| Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer. | Markoviฤ I et al. | โ | 2020 | โ |
| Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy. | Castro-Sanchez P et al. | โ | 2020 | โ |
| Pathophysiology of diabetes: An overview. | Banday MZ et al. | โ | 2020 | โ |
| Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants. | Crouch DJM et al. | โ | 2020 | โ |
| Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts. | Kirak O et al. | โ | 2020 | โ |
| Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine. | Niechcial A et al. | โ | 2020 | โ |
| Primary biliary cholangitis: pathogenesis and therapeutic opportunities. | Gulamhusein AF et al. | โ | 2020 | โ |
| Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance. | Hering L et al. | โ | 2020 | โ |
| PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. | Flosbach M et al. | โ | 2020 | โ |
| PTPN2 negatively regulates macrophage inflammation in atherosclerosis. | Hu X et al. | โ | 2020 | โ |
| Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes. | Forgetta V et al. | โ | 2020 | โ |
| Regulatory T Cells and Human Disease. | Sakaguchi S et al. | โ | 2020 | โ |
| [The analysis of association between multiple sclerosis and genetic markers identified in genome-wide association studies]. | Timasheva YR et al. | โ | 2020 | โ |
| The effects of long non-coding ribonucleic acids on various cellular components in rheumatoid arthritis. | Fang Y et al. | โ | 2020 | โ |
| The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor. | Wawrusiewicz-Kurylonek N et al. | โ | 2020 | โ |
| The Role of Epigenetics in Type 1 Diabetes. | Xie Z et al. | โ | 2020 | โ |
| The Role of Protein Tyrosine Phosphatases in Inflammasome Activation. | Spalinger MR et al. | โ | 2020 | โ |
| The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes. | Clark M et al. | โ | 2020 | โ |
| Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases. | Ohkura N et al. | โ | 2020 | โ |
| Truncated tests for combining evidence of summary statistics. | Bu D et al. | โ | 2020 | โ |
| Type 1 diabetes: genes associated with disease development. | Klak M et al. | โ | 2020 | โ |
| Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis. | Zhai N et al. | โ | 2020 | โ |
| Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. | Gudmundsdottir V et al. | โ | 2020 | โ |
| Aberrant expression of alternative splicing variants in multiple sclerosis - A systematic review. | Hecker M et al. | โ | 2019 | โ |
| Anti-IL-7 receptor ฮฑ monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study. | Ellis J et al. | โ | 2019 | โ |
| Associations between PTPN2 gene polymorphisms and psoriasis in Northeastern China. | Mei Q et al. | โ | 2019 | โ |
| Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rฮฑ expression. | Lundtoft C et al. | โ | 2019 | โ |
| Autophagy in the renewal, differentiation and homeostasis of immune cells. | Clarke AJ et al. | โ | 2019 | โ |
| Breakdown of multiple sclerosis genetics to identify an integrated disease network and potential variant mechanisms. | Shepard CJ et al. | โ | 2019 | โ |
| CD4<sup>+</sup> T-Cells With High Common ฮณ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes. | Seyfarth J et al. | โ | 2019 | โ |
| Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk. | Pรถllรคnen PM et al. | โ | 2019 | โ |
| Combining anti-IL-7Rฮฑ antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes. | Vazquez-Mateo C et al. | โ | 2019 | โ |
| Deleterious and Oncogenic Mutations in the <i>IL7RA</i>. | Campos LW et al. | โ | 2019 | โ |
| Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells. | Anderson W et al. | โ | 2019 | โ |
| Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints. | Chang LS et al. | โ | 2019 | โ |
| Extending Classification Algorithms to Case-Control Studies. | Stanfill B et al. | โ | 2019 | โ |
| Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes. | Johnson MB et al. | โ | 2019 | โ |
| Genetics Coming of Age in Type 1 Diabetes. | Cerolsaletti K et al. | โ | 2019 | โ |
| Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis. | Kottyan LC et al. | โ | 2019 | โ |
| Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study. | Zhu M et al. | โ | 2019 | โ |
| IL-7R gene polymorphisms among patients with rheumatoid arthritis: A case-control study. | Bai M et al. | โ | 2019 | โ |
| Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjรถgren Syndrome-like Inflammation. | Ciecko AE et al. | โ | 2019 | โ |
| Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. | Dodd GT et al. | โ | 2019 | โ |
| Loss of MafA and MafB expression promotes islet inflammation. | Singh T et al. | โ | 2019 | โ |
| Opposing roles of endothelial and leukocyte-expressed IL-7Rฮฑ in the regulation of psoriasis-like skin inflammation. | Vranova M et al. | โ | 2019 | โ |
| Retracted: Epigallocatechin gallate ameliorates morphological changes of pancreatic islets in diabetic mice and downregulates blood sugar level by inhibiting the accumulation of AGE-RAGE. | Feng Z et al. | โ | 2019 | โ |
| Shared genes between Alzheimer's disease and ischemic stroke. | Wei CJ et al. | โ | 2019 | โ |
| T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities. | Wiede F et al. | โ | 2019 | โ |
| The Association between <i>rs2292239</i> Polymorphism in <i>ERBB3</i> Gene and Type 1 Diabetes: A Meta-Analysis. | Wang D et al. | โ | 2019 | โ |
| The association between rs1893217, rs478582 in PTPN2 and T1D risk with different diagnosed age, and related clinical characteristics in Chinese Han population. | Chen S et al. | โ | 2019 | โ |
| The Autoimmune Disorder Susceptibility Gene <i>CLEC16A</i> Restrains NK Cell Function in YTS NK Cell Line and <i>Clec16a</i> Knockout Mice. | Pandey R et al. | โ | 2019 | โ |
| The epigenetic regulator ATF7ip inhibits <i>Il2</i> expression, regulating Th17 responses. | Sin JH et al. | โ | 2019 | โ |
| The Genetic Contribution to Type 1 Diabetes. | Bakay M et al. | โ | 2019 | โ |
| T Regulatory Cells From Non-obese Diabetic Mice Show Low Responsiveness to IL-2 Stimulation and Exhibit Differential Expression of Anergy-Related and Ubiquitination Factors. | Godoy GJ et al. | โ | 2019 | โ |
| Validation of Identified Susceptible Gene Variants for New-Onset Diabetes in Renal Transplant Recipients. | Hwang HS et al. | โ | 2019 | โ |
| Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin-triggered typeย 1 diabetes. | Onuma H et al. | โ | 2019 | โ |
| Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation. | Wan X et al. | โ | 2018 | โ |
| Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population. | Allam G et al. | โ | 2018 | โ |
| Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs. | Haider MZ et al. | โ | 2018 | โ |
| CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. | Pandey R et al. | โ | 2018 | โ |
| Collective effects of common single nucleotide polymorphisms and genetic risk prediction in type 1 diabetes. | Gui Y et al. | โ | 2018 | โ |
| Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan. | Tung YC et al. | โ | 2018 | โ |
| Detection and Characterization of CD8<sup>+</sup> Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes. | Vignali D et al. | โ | 2018 | โ |
| Donor Genotype in the Interleukin-7 Receptor ฮฑ-Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. | Kielsen K et al. | โ | 2018 | โ |
| Genetic Polymorphisms Associated with the NeutrophilโปLymphocyte Ratio and Their Clinical Implications for Metabolic Risk Factors. | Park B et al. | โ | 2018 | โ |
| Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. | Fung JN et al. | โ | 2018 | โ |
| Genetics of type 1 diabetes. | Redondo MJ et al. | โ | 2018 | โ |
| Gut Microbiota and Type 1 Diabetes. | Han H et al. | โ | 2018 | โ |
| IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates. | Belarif L et al. | โ | 2018 | โ |
| Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes. | Andreone L et al. | โ | 2018 | โ |
| Interleukin-7 receptor ฮฑ-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes. | Seyfarth J et al. | โ | 2018 | โ |
| [Next generation biobanking: the challenge of data]. | Dagher G et al. | โ | 2018 | โ |
| Precision medicine in diabetes prevention, classification and management. | Xie F et al. | โ | 2018 | โ |
| PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer. | Spalinger MR et al. | โ | 2018 | โ |
| Revisiting IL-2: Biology and therapeutic prospects. | Abbas AK et al. | โ | 2018 | โ |
| RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia. | Pineda-Trujillo N et al. | โ | 2018 | โ |
| The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5ย years of age. | Inshaw JRJ et al. | โ | 2018 | โ |
| The Common Cytokine Receptor ฮณ Chain Family of Cytokines. | Lin JX et al. | โ | 2018 | โ |
| The genetic architecture of type 1 diabetes mellitus. | Nyaga DM et al. | โ | 2018 | โ |
| The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. | Chen YG et al. | โ | 2018 | โ |
| Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. | Lundtoft C et al. | โ | 2017 | โ |
| Antibiotics, gut microbiota, environment in early life and type 1 diabetes. | Hu Y et al. | โ | 2017 | โ |
| Apoptosis of pancreatic ฮฒ-cells in Type 1 diabetes. | Tomita T | โ | 2017 | โ |
| Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes. | Zhao LP et al. | โ | 2017 | โ |
| Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility. | Pรถllรคnen PM et al. | โ | 2017 | โ |
| Clinical worthlessness of genetic prediction of common forms of diabetes mellitus and related chronic complications: A position statement of the Italian Society of Diabetology. | Buzzetti R et al. | โ | 2017 | โ |
| Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes. | Mullen Y | โ | 2017 | โ |
| Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma. | Ghassem-Zadeh S et al. | โ | 2017 | โ |
| Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression. | Ram R et al. | โ | 2017 | โ |
| GATE: an efficient procedure in study of pleiotropic genetic associations. | Zhang W et al. | โ | 2017 | โ |
| Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. | Grassmann F et al. | โ | 2017 | โ |
| Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis. | Redondo MJ et al. | โ | 2017 | โ |
| Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies. | Langlais D et al. | โ | 2017 | โ |
| Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. | Galarza-Muรฑoz G et al. | โ | 2017 | โ |
| Identification of PTPN22, ST6GAL1 and JAZF1 as psoriasis risk genes demonstrates shared pathogenesis between psoriasis and diabetes. | Wang H et al. | โ | 2017 | โ |
| Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques. | Steele AK et al. | โ | 2017 | โ |
| Interleukin-7 and Immunosenescence. | Nguyen V et al. | โ | 2017 | โ |
| In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. | Manguso RT et al. | โ | 2017 | โ |
| Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes. | Wallet MA et al. | โ | 2017 | โ |
| LncRNAs: key players and novel insights into diabetes mellitus. | He X et al. | โ | 2017 | โ |
| Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells. | Kasela S et al. | โ | 2017 | โ |
| Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3<sup>+</sup>IL-17<sup>+</sup> cells. | Marwaha AK et al. | โ | 2017 | โ |
| PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity. | Wiede F et al. | โ | 2017 | โ |
| PTPN2 regulates T cell lineage commitment and ฮฑฮฒ versus ฮณฮด specification. | Wiede F et al. | โ | 2017 | โ |
| Reevaluation of SNP heritability in complex human traits. | Speed D et al. | โ | 2017 | โ |
| Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it? | Hull CM et al. | โ | 2017 | โ |
| T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells. | Krishnan M et al. | โ | 2017 | โ |
| The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications. | Say YH et al. | โ | 2017 | โ |
| The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreaticย inflammation. | Dou Y et al. | โ | 2017 | โ |
| Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis. | Stรธrling J et al. | โ | 2017 | โ |
| Type 1 diabetes genome-wide association studies: not to be lost in translation. | Pociot F | โ | 2017 | โ |
| Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice. | Haddad CS et al. | โ | 2016 | โ |
| Association of CD247 (CD3ฮถ) gene polymorphisms with T1D and AITD in the population of northern Sweden. | Holmberg D et al. | โ | 2016 | โ |
| Association of rs6822844 within the KIAA1109/TENR/IL2/IL21 locus with rheumatoid arthritis in the Algerian population. | Louahchi S et al. | โ | 2016 | โ |
| Association study of <i>IL2RA</i> and <i>CTLA4</i> Gene Variants with Type I Diabetes Mellitus in children in the northwest of Iran. | Ranjouri MR et al. | โ | 2016 | โ |
| Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations. | Meierhofer D et al. | โ | 2016 | โ |
| Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics. | You S et al. | โ | 2016 | โ |
| Biomarkers of ฮฒ-Cell Stress and Death in Type 1 Diabetes. | Mirmira RG et al. | โ | 2016 | โ |
| CD4 T cell differentiation in type 1 diabetes. | Walker LS et al. | โ | 2016 | โ |
| Chromosome 18q deletion syndrome with autoimmune diabetes mellitus: putative genomic loci for autoimmunity and immunodeficiency. | Hogendorf A et al. | โ | 2016 | โ |
| Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency. | Bronson PG et al. | โ | 2016 | โ |
| Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells. | You L et al. | โ | 2016 | โ |
| Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data. | Sanjak JS et al. | โ | 2016 | โ |
| Estimating the Ages of Selection Signals from Different Epochs in Human History. | Nakagome S et al. | โ | 2016 | โ |
| Evaluation of Multiple Diagnostic Indicators in Comparison to the Intestinal Biopsy as the Golden Standard in Diagnosing Celiac Disease in Children. | Hollรฉn E et al. | โ | 2016 | โ |
| Evidence of ERBB3 gene association with rheumatoid arthritis predisposition. | Chatzikyriakidou A et al. | โ | 2016 | โ |
| Genes associated with diabetes: potential for novel therapeutic targets? | Hara K et al. | โ | 2016 | โ |
| Genetic variants in ANCA-associated vasculitis: a meta-analysis. | Rahmattulla C et al. | โ | 2016 | โ |
| Gut microbiota, obesity and diabetes. | Patterson E et al. | โ | 2016 | โ |
| Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model. | Yu C et al. | โ | 2016 | โ |
| New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs. | Pouchรฉ L et al. | โ | 2016 | โ |
| New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2. | Pรฉrol L et al. | โ | 2016 | โ |
| Next generation sequencing: implications in personalized medicine and pharmacogenomics. | Rabbani B et al. | โ | 2016 | โ |
| Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. | He L et al. | โ | 2016 | โ |
| Polymorphisms of the Toll-Like Receptor-3 Gene in Autoimmune Adrenal Failure and Type 1 Diabetes in Polish Patients. | Fichna M et al. | โ | 2016 | โ |
| Prevalence of selective immunoglobulin A deficiency in Greek children and adolescents with type 1 diabetes. | Giza S et al. | โ | 2016 | โ |
| Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection. | Fodil N et al. | โ | 2016 | โ |
| Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease. | Spalinger MR et al. | โ | 2016 | โ |
| PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection. | Maine CJ et al. | โ | 2016 | โ |
| Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor ฮฑ antibody in cynomolgus monkeys. | Kern B et al. | โ | 2016 | โ |
| Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. | Todd JA et al. | โ | 2016 | โ |
| Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility. | Ram R et al. | โ | 2016 | โ |
| Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes. | Ge Y et al. | โ | 2016 | โ |
| Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation. | Racimo F | โ | 2016 | โ |
| The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. | Kaur S et al. | โ | 2016 | โ |
| The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms. | Chen Y et al. | โ | 2016 | โ |
| The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. | Slattery J et al. | โ | 2016 | โ |
| Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment. | Hotta-Iwamura C et al. | โ | 2016 | โ |
| A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. | Sarmiento J et al. | โ | 2015 | โ |
| Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases. | Riedhammer C et al. | โ | 2015 | โ |
| A review of 18p deletions. | Hasi-Zogaj M et al. | โ | 2015 | โ |
| Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. | Lee YH et al. | โ | 2015 | โ |
| Association of 32 type 1 diabetes risk loci in Pakistani patients. | Kiani AK et al. | โ | 2015 | โ |
| Association of IL-21 polymorphisms (rs907715, rs2221903) with susceptibility to multiple autoimmune diseases: a meta-analysis. | Liu J et al. | โ | 2015 | โ |
| Balancing natural killer cell activation through paired receptors. | Martinet L et al. | โ | 2015 | โ |
| CD226 rs727088A>G polymorphism increases the susceptibility to gastric cancer in Chinese populations. | Zhang C et al. | โ | 2015 | โ |
| CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. | Wang L et al. | โ | 2015 | โ |
| Decreased serum level of IL-7 in patients with active Graves' disease. | Motylewska E et al. | โ | 2015 | โ |
| Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes. | Cooper NJ et al. | โ | 2015 | โ |
| Differences in B7 and CD28 family gene expression in the peripheral blood between newly diagnosed young-onset and adult-onset type 1 diabetes patients. | Pruul K et al. | โ | 2015 | โ |
| Emerging role of long noncoding RNAs in autoimmune diseases. | Wu GC et al. | โ | 2015 | โ |
| Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis. | Ellis JA et al. | โ | 2015 | โ |
| Evaluation of European coeliac disease risk variants in a north Indian population. | Senapati S et al. | โ | 2015 | โ |
| Exogenous IL-2 controls the balance in Th1, Th17, and Treg cell distribution in patients with progressive rheumatoid arthritis treated with TNF-alpha inhibitors. | Kosmaczewska A et al. | โ | 2015 | โ |
| Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. | Onengut-Gumuscu S et al. | โ | 2015 | โ |
| Follicular helper T cell signature in type 1 diabetes. | Kenefeck R et al. | โ | 2015 | โ |
| Gene set enrichment analysis of pathways and transcription factors associated with diabetic retinopathy using a microarray dataset. | He K et al. | โ | 2015 | โ |
| Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus. | Peng H et al. | โ | 2015 | โ |
| Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse. | Motta VN et al. | โ | 2015 | โ |
| IL7R gene expression network associates with human healthy ageing. | Passtoors WM et al. | โ | 2015 | โ |
| Immunogenetics of type 1 diabetes: A comprehensive review. | Noble JA | โ | 2015 | โ |
| Immunogenetics of type 1 diabetes mellitus. | Morran MP et al. | โ | 2015 | โ |
| Interleukin-2 and subunit alpha of its soluble receptor in autoimmune Addison's disease--an association study and expression analysis. | Fichna M et al. | โ | 2015 | โ |
| Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran. | Gharibi T et al. | โ | 2015 | โ |
| Latent autoimmune diabetes of the adult: current knowledge and uncertainty. | Laugesen E et al. | โ | 2015 | โ |
| Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. | Rosenzwajg M et al. | โ | 2015 | โ |
| Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis. | Salmond RJ et al. | โ | 2015 | โ |
| Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis. | van Luijn MM et al. | โ | 2015 | โ |
| Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function. | Piรฉdavent-Salomon M et al. | โ | 2015 | โ |
| Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes. | Yang JH et al. | โ | 2015 | โ |
| No association between rs6897932 in the gene encoding interleukin-7 receptor ฮฑ and low-grade inflammation or self-reported health - results from the Danish Blood Donor Study. | Hartling HJ et al. | โ | 2015 | โ |
| Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease. | Lempainen J et al. | โ | 2015 | โ |
| Pathogenesis of Systemic Sclerosis. | Pattanaik D et al. | โ | 2015 | โ |
| Phosphonate derivatives of tetraazamacrocycles as new inhibitors of protein tyrosine phosphatases. | Kobzar OL et al. | โ | 2015 | โ |
| Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). | Thorsen SU et al. | โ | 2015 | โ |
| Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. | Burkett PR et al. | โ | 2015 | โ |
| Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. | Michels A et al. | โ | 2015 | โ |
| Progress in understanding type 1 diabetes through its genetic overlap with other autoimmune diseases. | Roizen JD et al. | โ | 2015 | โ |
| Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts. | Aradi B et al. | โ | 2015 | โ |
| Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study. | Truman LA et al. | โ | 2015 | โ |
| PTPN2 controls differentiation of CD4โบ T cells and limits intestinal inflammation and intestinal dysbiosis. | Spalinger MR et al. | โ | 2015 | โ |
| Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation. | Spalinger MR et al. | โ | 2015 | โ |
| T cells in the control of organ-specific autoimmunity. | Bluestone JA et al. | โ | 2015 | โ |
| The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. | Schuster C et al. | โ | 2015 | โ |
| Therapeutic window of interleukin-2 for autoimmune diseases. | Tang Q | โ | 2015 | โ |
| Time-varying correlations between delta EEG power and heart rate variability in midlife women: the SWAN Sleep Study. | Rothenberger SD et al. | โ | 2015 | โ |
| Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus. | Assmann TS et al. | โ | 2015 | โ |
| Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNฮณ Regulation. | Quinn EM et al. | โ | 2015 | โ |
| Type 1 diabetes and gut microbiota: Friend or foe? | Hu C et al. | โ | 2015 | โ |
| 12q24 locus association with type 1 diabetes: SH2B3 or ATXN2? | Auburger G et al. | โ | 2014 | โ |
| A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. | Shameer K et al. | โ | 2014 | โ |
| A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes. | Zanda M et al. | โ | 2014 | โ |
| A humanized mouse model of autoimmune insulitis. | Viehmann Milam AA et al. | โ | 2014 | โ |
| A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations. | Evangelou M et al. | โ | 2014 | โ |
| Analysis of the expression of candidate genes for type 1 diabetes susceptibility in T cells. | Hisanaga-Oishi Y et al. | โ | 2014 | โ |
| Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development. | Chow IT et al. | โ | 2014 | โ |
| Association of a single-nucleotide polymorphism in the SH2B3 gene with JAK2V617F-positive myeloproliferative neoplasms. | Lesteven E et al. | โ | 2014 | โ |
| Association of the C-type lectin-like domain family-16A (CLEC16A) gene polymorphisms with acute coronary syndrome in Mexican patients. | Vargas-Alarcon G et al. | โ | 2014 | โ |
| Associations between TNF gene polymorphisms (-308 A/G, -238 A/G, -1031 C/T and -857 T/C) and genetic susceptibility to T1D: a meta-analysis. | Wen PF et al. | โ | 2014 | โ |
| Autoimmune diseases association study with the KIAA1109-IL2-IL21 region in a Tunisian population. | Bouzid D et al. | โ | 2014 | โ |
| Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. | Wu DJ et al. | โ | 2014 | โ |
| CD226 rs763361 is associated with the susceptibility to type 1 diabetes and greater frequency of GAD65 autoantibody in a Brazilian cohort. | Mattana TC et al. | โ | 2014 | โ |
| Clinical Case of Immune Dysregulation, Polyendocrinopaty, Enteropathy, X-Linked (IPEX) Syndrome with Severe Immune Deficiency and Late Onset of Endocrinopathy and Enteropathy. | Savova R et al. | โ | 2014 | โ |
| Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisians. | Zouidi F et al. | โ | 2014 | โ |
| Contribution of VDR polymorphisms to type 1 diabetes susceptibility: Systematic review of case-control studies and meta-analysis. | Tizaoui K et al. | โ | 2014 | โ |
| DNAM-1 control of natural killer cells functions through nectin and nectin-like proteins. | de Andrade LF et al. | โ | 2014 | โ |
| Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. | Winkler C et al. | โ | 2014 | โ |
| Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. | Tomlinson MJ et al. | โ | 2014 | โ |
| Forkhead box P3: the peacekeeper of the immune system. | Passerini L et al. | โ | 2014 | โ |
| Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus. | Zouk H et al. | โ | 2014 | โ |
| Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. | Zouk H et al. | โ | 2014 | โ |
| Gene-Gene Interaction between LCE and CLEC16A Increases the Risk of Psoriasis in a Chinese Population. | Wang J et al. | โ | 2014 | โ |
| Genetic and epigenetic risk factors for diabetic kidney disease. | McKnight AJ et al. | โ | 2014 | โ |
| Genetic Epidemiology of Psoriasis. | Gupta R et al. | โ | 2014 | โ |
| Genetics of diabetes--are we missing the genes or the disease? | Groop L et al. | โ | 2014 | โ |
| Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. | Basile KJ et al. | โ | 2014 | โ |
| Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. | Ferreira MA et al. | โ | 2014 | โ |
| Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. | Olsson AH et al. | โ | 2014 | โ |
| Genome-wide association study identifies two novel Loci with sex-specific effects for type 2 diabetes mellitus and glycemic traits in a korean population. | Go MJ et al. | โ | 2014 | โ |
| High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage. | Merry TL et al. | โ | 2014 | โ |
| HLA associations in schizophrenia: are we re-discovering the wheel? | Kodavali CV et al. | โ | 2014 | โ |
| Human cytomegalovirus and autoimmune disease. | Halenius A et al. | โ | 2014 | โ |
| Hunting autoimmune disease genes in NOD: early steps on a long road to somewhere important (hopefully). | Wakeland EK | โ | 2014 | โ |
| IBD candidate genes and intestinal barrier regulation. | McCole DF | โ | 2014 | โ |
| Identification of novel risk genes associated with typeย 1 diabetes mellitus using a genome-wide gene-based association analysis. | Qiu YH et al. | โ | 2014 | โ |
| Interleukin 2 in the pathogenesis and therapy of type 1 diabetes. | Rosenzwajg M et al. | โ | 2014 | โ |
| Interleukin-7 receptor single nucleotide polymorphism rs6897932 (C/T) and the susceptibility to systemic lupus erythematosus. | Wang XS et al. | โ | 2014 | โ |
| Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications. | Magyari L et al. | โ | 2014 | โ |
| lncRNAs: insights into their function and mechanics in underlying disorders. | Li X et al. | โ | 2014 | โ |
| Lnk prevents inflammatory CD8โบ T-cell proliferation and contributes to intestinal homeostasis. | Katayama H et al. | โ | 2014 | โ |
| Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-ฮณ-producing T cells. | Mori T et al. | โ | 2014 | โ |
| Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation. | Mehlhop-Williams ER et al. | โ | 2014 | โ |
| Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. | Kilarski LL et al. | โ | 2014 | โ |
| Microbiome manipulation modifies sex-specific risk for autoimmunity. | Markle JG et al. | โ | 2014 | โ |
| Molecular mechanisms in autoimmune type 1 diabetes: a critical review. | Xie Z et al. | โ | 2014 | โ |
| Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults. | Basile KJ et al. | โ | 2014 | โ |
| Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. | Namjou B et al. | โ | 2014 | โ |
| Polymorphism in interleukin-7 receptor ฮฑ gene is associated with faster CD4โบ T-cell recovery after initiation of combination antiretroviral therapy. | Hartling HJ et al. | โ | 2014 | โ |
| Polymorphisms in the TLR3 gene are associated with risk for type 1 diabetes mellitus. | Assmann TS et al. | โ | 2014 | โ |
| Principal component analysis characterizes shared pathogenetics from genome-wide association studies. | Chang D et al. | โ | 2014 | โ |
| Protein phosphatases in pancreatic islets. | Ortsรคter H et al. | โ | 2014 | โ |
| PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells. | Maine CJ et al. | โ | 2014 | โ |
| PTPN2 attenuates T-cell lymphopenia-induced proliferation. | Wiede F et al. | โ | 2014 | โ |
| PTPN2 gene polymorphisms are associated with type 1 diabetes mellitus in Brazilian subjects? | Rheinheimer J et al. | โ | 2014 | โ |
| PTPN2 restrains CD8โบ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice. | Wiede F et al. | โ | 2014 | โ |
| Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial. | Waldron-Lynch F et al. | โ | 2014 | โ |
| Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance. | Gupta S et al. | โ | 2014 | โ |
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. | Cho MH et al. | โ | 2014 | โ |
| Signals and pathways controlling regulatory T cells. | Huynh A et al. | โ | 2014 | โ |
| The diabetes susceptibility gene Clec16a regulates mitophagy. | Soleimanpour SA et al. | โ | 2014 | โ |
| The genetics of juvenile idiopathic arthritis: current understanding and future prospects. | Cobb JE et al. | โ | 2014 | โ |
| The impact of anti-inflammatory cytokines on the pancreatic ฮฒ-cell. | Russell MA et al. | โ | 2014 | โ |
| The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: the 'autophagy' hypothesis. | Fierabracci A | โ | 2014 | โ |
| The roles of genetic factors in uveitis and their clinical significance. | Yang MM et al. | โ | 2014 | โ |
| The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil. | Rheinheimer J et al. | โ | 2014 | โ |
| The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population. | Wang X et al. | โ | 2014 | โ |
| Towards a liquid self: how time, geography, and life experiences reshape the biological identity. | Grignolio A et al. | โ | 2014 | โ |
| Type I diabetes mellitus: genetic factors and presumptive enteroviral etiology or protection. | Precechtelova J et al. | โ | 2014 | โ |
| Altered immune regulation in type 1 diabetes. | Zรณka A et al. | โ | 2013 | โ |
| Analytical strategies for large imaging genetic datasets: experiences from the IMAGEN study. | Nymberg C et al. | โ | 2013 | โ |
| Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach. | Portuesi R et al. | โ | 2013 | โ |
| Association between two genetic variants of CD226 gene and Cervical Squamous Cell Carcinoma: a case-control study. | Shi S et al. | โ | 2013 | โ |
| Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis. | Cen H et al. | โ | 2013 | โ |
| Association study of STAT4 polymorphisms and type 1 diabetes in Northeastern Chinese Han population. | Bi C et al. | โ | 2013 | โ |
| Autoimmune effector memory T cells: the bad and the good. | Devarajan P et al. | โ | 2013 | โ |
| Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and ฮฒ-cell apoptosis. | Santin I et al. | โ | 2013 | โ |
| CD226 Gly307Ser association with multiple autoimmune diseases: a meta-analysis. | Qiu ZX et al. | โ | 2013 | โ |
| Clinical implications of shared genetics and pathogenesis in autoimmune diseases. | Zhernakova A et al. | โ | 2013 | โ |
| Concentration and activity of the soluble form of the interleukin-7 receptor ฮฑ in type 1 diabetes identifies an interplay between hyperglycemia and immune function. | Monti P et al. | โ | 2013 | โ |
| CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset. | Belot MP et al. | โ | 2013 | โ |
| Definition and refinement of the 7q36.3 duplication region associated with schizophrenia. | Aleksic B et al. | โ | 2013 | โ |
| Distinct genetic control of autoimmune neuropathy and diabetes inย the non-obese diabetic background. | Bour-Jordan H et al. | โ | 2013 | โ |
| Early-onset, coexisting autoimmunity and decreased HLA-mediated susceptibility are the characteristics of diabetes in Down syndrome. | Aitken RJ et al. | โ | 2013 | โ |
| Emerging function of fat mass and obesity-associated protein (fto). | Mรผller TD et al. | โ | 2013 | โ |
| Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes. | Bollyky JB et al. | โ | 2013 | โ |
| Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. | Cรฉnit MC et al. | โ | 2013 | โ |
| Expression of B7 and CD28 family genes in newly diagnosed type 1 diabetes. | Pruul K et al. | โ | 2013 | โ |
| From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. | Berge T et al. | โ | 2013 | โ |
| Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy. | Maiti AK et al. | โ | 2013 | โ |
| Genes involved in type 1 diabetes: an update. | Bakay M et al. | โ | 2013 | โ |
| Genetic and epigenetic factors in etiology of diabetes mellitus type 1. | Stankov K et al. | โ | 2013 | โ |
| Genetic association studies in female reproduction: from candidate-gene approaches to genome-wide mapping. | Zhao H et al. | โ | 2013 | โ |
| Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. | Lin X et al. | โ | 2013 | โ |
| Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. | Cordell HJ et al. | โ | 2013 | โ |
| Genome-wide search for exonic variants affecting translational efficiency. | Li Q et al. | โ | 2013 | โ |
| GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. | Simmonds MJ | โ | 2013 | โ |
| High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. | Ellinghaus D et al. | โ | 2013 | โ |
| Homeostatic T cell proliferation after islet transplantation. | Monti P et al. | โ | 2013 | โ |
| Identification of INS and KCNJ11 gene mutations in type 1B diabetes in Japanese children with onset of diabetes before 5 years of age. | Moritani M et al. | โ | 2013 | โ |
| Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. | Cobb JE et al. | โ | 2013 | โ |
| IL-2 therapy in type 1 diabetes: "Trials" and tribulations. | Long SA et al. | โ | 2013 | โ |
| Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management. | Caforio AL et al. | โ | 2013 | โ |
| Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. | Diaz-Gallo LM et al. | โ | 2013 | โ |
| Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. | Carbonetto P et al. | โ | 2013 | โ |
| Interleukin 1B rs16944 G>A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. | Zheng L et al. | โ | 2013 | โ |
| Interleukin-7: Fuel for the autoimmune attack. | Dooms H | โ | 2013 | โ |
| Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury. | Predescu DN et al. | โ | 2013 | โ |
| Intersection between genetic polymorphisms and immune deviation in type 1 diabetes. | Long A et al. | โ | 2013 | โ |
| Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY). | Frederiksen B et al. | โ | 2013 | โ |
| Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients. | Cerosaletti K et al. | โ | 2013 | โ |
| Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. | Leikfoss IS et al. | โ | 2013 | โ |
| New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. | Rowlan JS et al. | โ | 2013 | โ |
| Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. | Erlich HA et al. | โ | 2013 | โ |
| Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility in Japanese rheumatoid arthritis patients. | Suzuki T et al. | โ | 2013 | โ |
| Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals. | Nokoff N et al. | โ | 2013 | โ |
| Perspectives of the relationship between IL-7 and autoimmune diseases. | Wang XS et al. | โ | 2013 | โ |
| Phosphatase regulation of intercellular junctions. | McCole DF | โ | 2013 | โ |
| Pleiotropy in complex traits: challenges and strategies. | Solovieff N et al. | โ | 2013 | โ |
| Polymorphic variant at the IL2 region is associated with type 1 diabetes and may affect serum levels of interleukin-2. | Fichna M et al. | โ | 2013 | โ |
| Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. | Aslibekyan S et al. | โ | 2013 | โ |
| Promoting regulation via the inhibition of DNAM-1 after transplantation. | Koyama M et al. | โ | 2013 | โ |
| PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis. | Tiganis T | โ | 2013 | โ |
| PUMA: a unified framework for penalized multiple regression analysis of GWAS data. | Hoffman GE et al. | โ | 2013 | โ |
| Recursive organizer (ROR): an analytic framework for sequence-based association analysis. | Zhao LP et al. | โ | 2013 | โ |
| Reproduction and immunity-driven natural selection in the human WFDC locus. | Ferreira Z et al. | โ | 2013 | โ |
| Role of cytokines in thymus- versus peripherally derived-regulatory T cell differentiation and function. | Goldstein JD et al. | โ | 2013 | โ |
| Role of the adaptor protein LNK in normal and malignant hematopoiesis. | Gery S et al. | โ | 2013 | โ |
| Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes. | Zhang Q et al. | โ | 2013 | โ |
| Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function. | Penrose HM et al. | โ | 2013 | โ |
| The association of -475 and -631 interleukin-2 gene polymorphism with multiple sclerosis in Iranian patients. | Sayad A et al. | โ | 2013 | โ |
| The changing landscape of type 1 diabetes: recent developments and future frontiers. | Vehik K et al. | โ | 2013 | โ |
| The development of genome-wide association studies and their application to complex diseases, including lupus. | Bentham J et al. | โ | 2013 | โ |
| The emerging global epidemic of type 1 diabetes. | Tuomilehto J | โ | 2013 | โ |
| The genetics of complex cholestatic disorders. | Hirschfield GM et al. | โ | 2013 | โ |
| The genetics of innate immunity sensors and human disease. | Pothlichet J et al. | โ | 2013 | โ |
| The pancreatic ฮฒ cell and type 1 diabetes: innocent bystander or active participant? | Soleimanpour SA et al. | โ | 2013 | โ |
| Thrombotic antiphospholipid syndrome shows strong haplotypic association with SH2B3-ATXN2 locus. | Ochoa E et al. | โ | 2013 | โ |
| Transmission disequilibrium analysis of 31 type 1 diabetes susceptibility loci in Finnish families. | Laine AP et al. | โ | 2013 | โ |
| Wedelolactone, a naturally occurring coumestan, enhances interferon-ฮณ signaling through inhibiting STAT1 protein dephosphorylation. | Chen Z et al. | โ | 2013 | โ |
| A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot. | Goodship JA et al. | โ | 2012 | โ |
| A comparison of Bayesian and frequentist approaches to incorporating external information for the prediction of prostate cancer risk. | Newcombe PJ et al. | โ | 2012 | โ |
| A functional framework for interpretation of genetic associations in T1D. | Nepom GT et al. | โ | 2012 | โ |
| Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes. | Gyllenberg A et al. | โ | 2012 | โ |
| A genetic association study of the CLEC12A gene in rheumatoid arthritis. | Michou L et al. | โ | 2012 | โ |
| A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis. | Bossini-Castillo L et al. | โ | 2012 | โ |
| ANKRD55 and DHCR7 are novel multiple sclerosis risk loci. | Alloza I et al. | โ | 2012 | โ |
| Anti-IL-7 receptor-ฮฑ reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. | Lee LF et al. | โ | 2012 | โ |
| Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank. | Pathak J et al. | โ | 2012 | โ |
| A single autoimmune T cell receptor recognizes more than a million different peptides. | Wooldridge L et al. | โ | 2012 | โ |
| Association between the CD226 rs763361 polymorphism and susceptibility to autoimmune diseases: a meta-analysis. | Song G et al. | โ | 2012 | โ |
| Association of genetic polymorphisms of interleukins with new-onset diabetes after transplantation in renal transplantation. | Kim YG et al. | โ | 2012 | โ |
| Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis. | Peng H et al. | โ | 2012 | โ |
| Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes. | Fradin D et al. | โ | 2012 | โ |
| A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes. | Winkler C et al. | โ | 2012 | โ |
| Autoimmune Addison disease: pathophysiology and genetic complexity. | Mitchell AL et al. | โ | 2012 | โ |
| Breakdown in peripheral tolerance in type 1 diabetes in mice and humans. | Jeker LT et al. | โ | 2012 | โ |
| Celiac disease: prevalence, diagnosis, pathogenesis and treatment. | Gujral N et al. | โ | 2012 | โ |
| Clinical features, diagnostic criteria and pathogenesis of diabetes mellitus. | Imam K | โ | 2012 | โ |
| Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology? | Hemminki K et al. | โ | 2012 | โ |
| Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling. | Fesel C et al. | โ | 2012 | โ |
| Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. | Yang MM et al. | โ | 2012 | โ |
| Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. | Scharl M et al. | โ | 2012 | โ |
| Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies. | Vandenbroeck K | โ | 2012 | โ |
| Disease liability prediction from large scale genotyping data using classifiers with a reject option. | Quevedo JR et al. | โ | 2012 | โ |
| Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function. | Kim S et al. | โ | 2012 | โ |
| Evidence for two independent associations with type 1 diabetes at the 12q13 locus. | Keene KL et al. | โ | 2012 | โ |
| Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. | Howson JM et al. | โ | 2012 | โ |
| Familial risks in understanding type 1 diabetes genetics. | Hemminki K | โ | 2012 | โ |
| From genes to characteristics of multiple sclerosis. | Harbo HF et al. | โ | 2012 | โ |
| From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era. | Baxter AG et al. | โ | 2012 | โ |
| Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. | Zhang Z et al. | โ | 2012 | โ |
| Genetic factors of autoimmune thyroid diseases in Japanese. | Ban Y | โ | 2012 | โ |
| Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. | Fairfax BP et al. | โ | 2012 | โ |
| Genetic variants in IFIH1 play opposite roles in the pathogenesis of psoriasis and chronic periodontitis. | Chen G et al. | โ | 2012 | โ |
| Genome-wide association analysis identifies three new breast cancer susceptibility loci. | Ghoussaini M et al. | โ | 2012 | โ |
| Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. | Shi Y et al. | โ | 2012 | โ |
| Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes. | Li CR et al. | โ | 2012 | โ |
| High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency. | Ferreira RC et al. | โ | 2012 | โ |
| Highlights from the 37th Annual Meeting for ISPAD, Miami. | Cho YH et al. | โ | 2012 | โ |
| HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13. | Asad S et al. | โ | 2012 | โ |
| Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. | Pietropaolo M et al. | โ | 2012 | โ |
| IL-15 inhibits IL-7Rฮฑ expression by memory-phenotype CD8โบ T cells in the bone marrow. | Quinci AC et al. | โ | 2012 | โ |
| IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. | Heninger AK et al. | โ | 2012 | โ |
| IL-7 in human health and disease. | Lundstrรถm W et al. | โ | 2012 | โ |
| IL-7 receptor ฮฑ blockade, an off-switch for autoreactive T cells. | Boettler T et al. | โ | 2012 | โ |
| Improved statistics for genome-wide interaction analysis. | Ueki M et al. | โ | 2012 | โ |
| Influence of type 1 diabetes genes on disease progression: similarities and differences between countries. | Lempainen J et al. | โ | 2012 | โ |
| Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. | Hernandez DG et al. | โ | 2012 | โ |
| Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets. | Van Belle TL et al. | โ | 2012 | โ |
| Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation. | Grigorian A et al. | โ | 2012 | โ |
| Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. | Hinks A et al. | โ | 2012 | โ |
| Involvement of CLEC16A in activation of astrocytes after LPS treated. | Wu X et al. | โ | 2012 | โ |
| LADA and T1D in Estonian population - two different genetic risk profiles. | Kisand K et al. | โ | 2012 | โ |
| Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. | Davison LJ et al. | โ | 2012 | โ |
| LYP inhibits T-cell activation when dissociated from CSK. | Vang T et al. | โ | 2012 | โ |
| Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-ฮณ2 gene and diabetic retinopathy in Caucasians and Asians. | Ma J et al. | โ | 2012 | โ |
| Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. | Chung SA et al. | โ | 2012 | โ |
| Novel associations for hypothyroidism include known autoimmune risk loci. | Eriksson N et al. | โ | 2012 | โ |
| Novel biomarkers in type 1 diabetes. | Jin Y et al. | โ | 2012 | โ |
| Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation. | Grigorian A et al. | โ | 2012 | โ |
| Presence of multiple independent effects in risk loci of common complex human diseases. | Ke X | โ | 2012 | โ |
| Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium. | Zhu Q et al. | โ | 2012 | โ |
| Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes. | Miao F et al. | โ | 2012 | โ |
| Promises and challenges of pharmacogenetics: an overview of study design, methodological and statistical issues. | Ross S et al. | โ | 2012 | โ |
| Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22. | Cerosaletti K et al. | โ | 2012 | โ |
| PTPN22 alters the development of regulatory T cells in the thymus. | Maine CJ et al. | โ | 2012 | โ |
| PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. | Glas J et al. | โ | 2012 | โ |
| Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. | Stanford SM et al. | โ | 2012 | โ |
| Role of the 12q24.12 locus in the onset of preeclampsia: an Italian case-control study. | Di Gaetano C et al. | โ | 2012 | โ |
| rs11203203 is associated with type 1 diabetes risk in population pre-screened for high-risk HLA-DR,DQ genotypes. | Johnson K et al. | โ | 2012 | โ |
| Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. | Wallace C et al. | โ | 2012 | โ |
| Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. | Wiede F et al. | โ | 2012 | โ |
| Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule. | Tollefsen S et al. | โ | 2012 | โ |
| Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. | Bulek AM et al. | โ | 2012 | โ |
| The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population. | Du Y et al. | โ | 2012 | โ |
| The Correlation between the CLEC16A Gene and Genetic Susceptibility to Type 1 Diabetes in Chinese Children. | Sang Y et al. | โ | 2012 | โ |
| The human IL-7 receptor gene: deletions, polymorphisms and mutations. | Mazzucchelli RI et al. | โ | 2012 | โ |
| The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. | Eizirik DL et al. | โ | 2012 | โ |
| The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond. | Roan F et al. | โ | 2012 | โ |
| The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation. | Scharl M et al. | โ | 2012 | โ |
| The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. | Moore F et al. | โ | 2012 | โ |
| The viral enterprises in autoimmunity: conversion of target cells into de novo APCs is the presage to autoimmunity. | Temajo NO et al. | โ | 2012 | โ |
| Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: transcript profile and therapeutic effects. | Lopez-Dee ZP et al. | โ | 2012 | โ |
| Tissue-specific alterations of PRL-1 and PRL-2 expression in cancer. | Dumaual CM et al. | โ | 2012 | โ |
| Twin studies in autoimmune disease: genetics, gender and environment. | Bogdanos DP et al. | โ | 2012 | โ |
| Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. | Garg G et al. | โ | 2012 | โ |
| [Type 1 diabetes mellitus: most recent advances in its pathogenesis and treatment]. | Zรณka A et al. | โ | 2012 | โ |
| Type 2 Diabetes Genetics: Beyond GWAS. | Sanghera DK et al. | โ | 2012 | โ |
| Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12. | Kurreeman FA et al. | โ | 2012 | โ |
| Why are C-section deliveries linked to childhood type 1 diabetes? | Vehik K et al. | โ | 2012 | โ |
| A flexible genome-wide bootstrap method that accounts for ranking and threshold-selection bias in GWAS interpretation and replication study design. | Faye LL et al. | โ | 2011 | โ |
| A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. | Bradfield JP et al. | โ | 2011 | โ |
| An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. | Swafford AD et al. | โ | 2011 | โ |
| Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis. | Stallhofer J et al. | โ | 2011 | โ |
| An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells. | Long SA et al. | โ | 2011 | โ |
| An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes. | Winkler C et al. | โ | 2011 | โ |
| A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes. | Espino-Paisan L et al. | โ | 2011 | โ |
| Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. | Reddy MV et al. | โ | 2011 | โ |
| Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. | Cunninghame Graham DS et al. | โ | 2011 | โ |
| Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis. | Dieudรฉ P et al. | โ | 2011 | โ |
| Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population. | Du Y et al. | โ | 2011 | โ |
| A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. | Budarf ML et al. | โ | 2011 | โ |
| Autoimmune polyendocrinopathy associated with ring chromosome 18. | Jain N et al. | โ | 2011 | โ |
| Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving. | Cagliani R et al. | โ | 2011 | โ |
| Beyond the hormone: insulin as an autoimmune target in type 1 diabetes. | Brezar V et al. | โ | 2011 | โ |
| Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells. | Cai CQ et al. | โ | 2011 | โ |
| Case records of the Massachusetts General Hospital: Case 7-2011: a 52-year-old man with upper respiratory symptoms and low oxygen saturation levels. | Pallais JC et al. | โ | 2011 | โ |
| CD155 on human vascular endothelial cells attenuates the acquisition of effector functions in CD8 T cells. | Escalante NK et al. | โ | 2011 | โ |
| CFH 184G as a genetic risk marker for anterior uveitis in Chinese females. | Yang MM et al. | โ | 2011 | โ |
| Clinical and immunological features of celiac disease in patients with Type 1 diabetes mellitus. | Volta U et al. | โ | 2011 | โ |
| Copy number variation in common disease. | Brand OJ et al. | โ | 2011 | โ |
| Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. | Bauler TJ et al. | โ | 2011 | โ |
| Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans. | Ferreira Z et al. | โ | 2011 | โ |
| Effect of genome-wide simultaneous hypotheses tests on the discovery rate. | Eyheramendy S et al. | โ | 2011 | โ |
| Evaluation of nanofluidics technology for high-throughput SNP genotyping in a clinical setting. | Chan M et al. | โ | 2011 | โ |
| Evidence of association with type 1 diabetes in the SLC11A1 gene region. | Yang JH et al. | โ | 2011 | โ |
| Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus. | Mero IL et al. | โ | 2011 | โ |
| Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. | Hughes T et al. | โ | 2011 | โ |
| From SNPs to genes: disease association at the gene level. | Lehne B et al. | โ | 2011 | โ |
| Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes. | Saleh NM et al. | โ | 2011 | โ |
| Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans. | Lo KS et al. | โ | 2011 | โ |
| Genetic predisposition to autoimmunity--what have we learned? | Rai E et al. | โ | 2011 | โ |
| Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention. | Ikegami H et al. | โ | 2011 | โ |
| Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. | Mkhikian H et al. | โ | 2011 | โ |
| Genetics of childhood obesity. | Zhao J et al. | โ | 2011 | โ |
| Genetics of infectious diseases: hidden etiologies and common pathways. | Orlova M et al. | โ | 2011 | โ |
| Genetics of multiple sclerosis. | Hoppenbrouwers IA et al. | โ | 2011 | โ |
| Genetics of rheumatoid arthritis: GWAS and beyond. | McAllister K et al. | โ | 2011 | โ |
| Genetics of type 1 diabetes. | Steck AK et al. | โ | 2011 | โ |
| Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk. | Einarsdottir E et al. | โ | 2011 | โ |
| Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. | Parรฉ G et al. | โ | 2011 | โ |
| Genome-wide association studies for discovery of genes involved in asthma. | Akhabir L et al. | โ | 2011 | โ |
| Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes. | Hakonarson H et al. | โ | 2011 | โ |
| Genome-wide association studies: results from the first few years and potential implications for clinical medicine. | Hirschhorn JN et al. | โ | 2011 | โ |
| Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. | Sacks DB et al. | โ | 2011 | โ |
| Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. | Sacks DB et al. | โ | 2011 | โ |
| HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion. | Williams RC et al. | โ | 2011 | โ |
| Human genetic susceptibility to intracellular pathogens. | Vannberg FO et al. | โ | 2011 | โ |
| Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions. | Brand OJ et al. | โ | 2011 | โ |
| Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. | Cooper JD et al. | โ | 2011 | โ |
| Insight from genome-wide association studies in rheumatoid arthritis and multiple sclerosis. | Suzuki A et al. | โ | 2011 | โ |
| Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. | Rotival M et al. | โ | 2011 | โ |
| Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/โB7 family. | Bour-Jordan H et al. | โ | 2011 | โ |
| Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. | Latiano A et al. | โ | 2011 | โ |
| Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. | Kim YJ et al. | โ | 2011 | โ |
| Mechanisms of tolerance. | Bluestone JA | โ | 2011 | โ |
| Meet me halfway: when genomics meets structural bioinformatics. | Gong S et al. | โ | 2011 | โ |
| Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. | Dehghan A et al. | โ | 2011 | โ |
| Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis. | Umeno J et al. | โ | 2011 | โ |
| No major genes in autoimmune thyroid diseases: complex segregation and epidemiological studies in a large Tunisian pedigree. | Bougacha-Elleuch N et al. | โ | 2011 | โ |
| Opposing functions of IL-2 and IL-7 in the regulation of immune responses. | Katzman SD et al. | โ | 2011 | โ |
| Planning a genome-wide association study: points to consider. | Hakonarson H et al. | โ | 2011 | โ |
| Polymorphisms in chromosome region 12q13 and their influence on age at onset of type 1 diabetes. | Espino-Paisan L et al. | โ | 2011 | โ |
| Polymorphisms in the innate immune IFIH1 gene, frequency of enterovirus in monthly fecal samples during infancy, and islet autoimmunity. | Witsรธ E et al. | โ | 2011 | โ |
| PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic ฮฒ-cell apoptosis via regulation of the BH3-only protein Bim. | Santin I et al. | โ | 2011 | โ |
| Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics. | Altmaier E et al. | โ | 2011 | โ |
| Recent findings in the genetics of blood pressure and hypertension traits. | Franceschini N et al. | โ | 2011 | โ |
| Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex. | Baschal EE et al. | โ | 2011 | โ |
| Selective IgA deficiency in autoimmune diseases. | Wang N et al. | โ | 2011 | โ |
| Shared genetics in coeliac disease and other immune-mediated diseases. | Gutierrez-Achury J et al. | โ | 2011 | โ |
| Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients. | Espino-Paisรกn L et al. | โ | 2011 | โ |
| T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. | Wiede F et al. | โ | 2011 | โ |
| T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. | Cheng G et al. | โ | 2011 | โ |
| The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling. | Devalliรจre J et al. | โ | 2011 | โ |
| The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients. | Lavrikova EY et al. | โ | 2011 | โ |
| The genetic basis of graves' disease. | Pลoski R et al. | โ | 2011 | โ |
| The genetics of blood pressure and hypertension: the role of rare variation. | Doris PA | โ | 2011 | โ |
| The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond. | Conforti-Andreoni C et al. | โ | 2011 | โ |
| The interleukin-7 receptor ฮฑ chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis. | Haas J et al. | โ | 2011 | โ |
| The past, present, and future of genetic associations in type 1 diabetes. | Baker PR et al. | โ | 2011 | โ |
| The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes. | Nielsen LB et al. | โ | 2011 | โ |
| The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis. | Gan EH et al. | โ | 2011 | โ |
| The search for the genetic contribution to autoimmune thyroid disease: the never ending story? | Simmonds MJ et al. | โ | 2011 | โ |
| Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9. | Janse M et al. | โ | 2011 | โ |
| Type 1 diabetes: etiology, immunology, and therapeutic strategies. | van Belle TL et al. | โ | 2011 | โ |
| Understanding type 1 diabetes through genetics: advances and prospects. | Polychronakos C et al. | โ | 2011 | โ |
| Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. | Zikherman J et al. | โ | 2011 | โ |
| Using stem cells to study and possibly treat type 1 diabetes. | Melton DA | โ | 2011 | โ |
| ฮฑ-Galactosylceramide ameliorates autoimmune diabetes in non-obese diabetic mice through a suppressive effect mediated by CD8+ T cells. | Chuang YP et al. | โ | 2011 | โ |
| A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus. | Lรถfgren SE et al. | โ | 2010 | โ |
| A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis. | Bronson PG et al. | โ | 2010 | โ |
| Accounting for chance in the calculus of autoimmune disease. | Moore DJ | โ | 2010 | โ |
| A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis. | Skinningsrud B et al. | โ | 2010 | โ |
| Adaptation and constraint at Toll-like receptors in primates. | Wlasiuk G et al. | โ | 2010 | โ |
| Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies. | Carey C et al. | โ | 2010 | โ |
| A genetic perspective on coeliac disease. | Trynka G et al. | โ | 2010 | โ |
| Allelic variants in the PHTF1-PTPN22, C12orf30 and CD226 regions as candidate susceptibility factors for the type 1 diabetes in the Estonian population. | Douroudis K et al. | โ | 2010 | โ |
| An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms. | Stene LC et al. | โ | 2010 | โ |
| A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. | Ban M et al. | โ | 2010 | โ |
| A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility. | Tan IK et al. | โ | 2010 | โ |
| Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. | Hong H et al. | โ | 2010 | โ |
| Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals. | Fujimaki T et al. | โ | 2010 | โ |
| Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians. | Benmansour J et al. | โ | 2010 | โ |
| Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. | Hinks A et al. | โ | 2010 | โ |
| A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the retina 4 project. | Rojas J et al. | โ | 2010 | โ |
| Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. | Fiorillo E et al. | โ | 2010 | โ |
| Autologous hematopoietic stem cell transplantation for childhood autoimmune disease. | Milanetti F et al. | โ | 2010 | โ |
| Blood pressure and human genetic variation in the general population. | Arora P et al. | โ | 2010 | โ |
| Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults? | Grant SF et al. | โ | 2010 | โ |
| Chromosomal region 16p13: further evidence of increased predisposition to immune diseases. | Martรญnez A et al. | โ | 2010 | โ |
| CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. | Bronson PG et al. | โ | 2010 | โ |
| Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus. | Maiti AK et al. | โ | 2010 | โ |
| Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases. | Zhong H et al. | โ | 2010 | โ |
| Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives. | Fรคndrich F et al. | โ | 2010 | โ |
| Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. | Long SA et al. | โ | 2010 | โ |
| Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. | Kleppe M et al. | โ | 2010 | โ |
| Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. | Schulte BM et al. | โ | 2010 | โ |
| Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations. | Lachance J | โ | 2010 | โ |
| Endocrine autoimmune disease: genetics become complex. | Wiebolt J et al. | โ | 2010 | โ |
| Etiology of type 1 diabetes. | Todd JA | โ | 2010 | โ |
| Evaluating variations of genotype calling: a potential source of spurious associations in genome-wide association studies. | Hong H et al. | โ | 2010 | โ |
| Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. | Laukens D et al. | โ | 2010 | โ |
| Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection. | Zhernakova A et al. | โ | 2010 | โ |
| Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases. | Bittles AH et al. | โ | 2010 | โ |
| Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. | Newby PR et al. | โ | 2010 | โ |
| Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. | Hoe E et al. | โ | 2010 | โ |
| Genetically dependent ERBB3 expression modulates antigen presenting cell function and type 1 diabetes risk. | Wang H et al. | โ | 2010 | โ |
| Genetic association analysis of LARS2 with type 2 diabetes. | Reiling E et al. | โ | 2010 | โ |
| Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trรธndelag Health Study. | Pettersen E et al. | โ | 2010 | โ |
| Genetics of atrial fibrillation: implications for future research directions and personalized medicine. | Lubitz SA et al. | โ | 2010 | โ |
| Genetics of type 1 diabetes: what's next? | Pociot F et al. | โ | 2010 | โ |
| Genetics of type 2 diabetes. | Smushkin G et al. | โ | 2010 | โ |
| Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. | Pierce BL et al. | โ | 2010 | โ |
| Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. | Ockinger J et al. | โ | 2010 | โ |
| Genetic variations associated with psoriasis and psoriatic arthritis found by genome-wide association. | Duffin KC et al. | โ | 2010 | โ |
| Genome-wide association analysis identifies three psoriasis susceptibility loci. | Stuart PE et al. | โ | 2010 | โ |
| Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test. | Abad-Grau MM et al. | โ | 2010 | โ |
| Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. | Stahl EA et al. | โ | 2010 | โ |
| Genome-wide data-mining of candidate human splice translational efficiency polymorphisms (STEPs) and an online database. | Raistrick CA et al. | โ | 2010 | โ |
| GWASs and the age of human as the model organism for autoimmune genetic research. | Plenge R | โ | 2010 | โ |
| Human behavioral informatics in genetic studies of neuropsychiatric disease: multivariate profile-based analysis. | Bloss CS et al. | โ | 2010 | โ |
| Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells. | Yamanouchi J et al. | โ | 2010 | โ |
| IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease. | d'Hennezel E et al. | โ | 2010 | โ |
| Immunologic endocrine disorders. | Michels AW et al. | โ | 2010 | โ |
| Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection. | Pezzolesi MG et al. | โ | 2010 | โ |
| In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. | Qu HQ et al. | โ | 2010 | โ |
| Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? | Smith TJ | โ | 2010 | โ |
| Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes. | Noso S et al. | โ | 2010 | โ |
| Integrating pathway analysis and genetics of gene expression for genome-wide association studies. | Zhong H et al. | โ | 2010 | โ |
| Leprosy and the adaptation of human toll-like receptor 1. | Wong SH et al. | โ | 2010 | โ |
| Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. | Zhong H et al. | โ | 2010 | โ |
| Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. | Stanford SM et al. | โ | 2010 | โ |
| MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. | Colli ML et al. | โ | 2010 | โ |
| Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. | Fraser HI et al. | โ | 2010 | โ |
| Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. | Maiti AK et al. | โ | 2010 | โ |
| Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. | Hollis-Moffatt JE et al. | โ | 2010 | โ |
| Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group. | Zhuang JJ et al. | โ | 2010 | โ |
| Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. | Hober D et al. | โ | 2010 | โ |
| Physiological insights gained from gene expression analysis in obesity and diabetes. | Keller MP et al. | โ | 2010 | โ |
| Polymorphisms in the genes encoding TGF-beta1, TNF-alpha, and IL-6 show association with type 1 diabetes mellitus in the Slovak population. | Javor J et al. | โ | 2010 | โ |
| Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. | Cavanillas ML et al. | โ | 2010 | โ |
| Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. | Boelaert K et al. | โ | 2010 | โ |
| Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. | Kim DJ et al. | โ | 2010 | โ |
| PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population. | Morgan AR et al. | โ | 2010 | โ |
| P-value based analysis for shared controls design in genome-wide association studies. | Zaykin DV et al. | โ | 2010 | โ |
| Recent advances in the genetics and genomics of asthma and related traits. | Sleiman PM et al. | โ | 2010 | โ |
| Recent advances in the genetics of systemic lupus erythematosus. | Flesher DL et al. | โ | 2010 | โ |
| Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. | Handunnetthi L et al. | โ | 2010 | โ |
| Screen and clean: a tool for identifying interactions in genome-wide association studies. | Wu J et al. | โ | 2010 | โ |
| Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects. | Klinker MW et al. | โ | 2010 | โ |
| SNP selection in genome-wide and candidate gene studies via penalized logistic regression. | Ayers KL et al. | โ | 2010 | โ |
| Sporadic cases are the norm for complex disease. | Yang J et al. | โ | 2010 | โ |
| Study of transcriptional effects in Cis at the IFIH1 locus. | Zouk H et al. | โ | 2010 | โ |
| Synthetic associations in the context of genome-wide association scan signals. | Orozco G et al. | โ | 2010 | โ |
| The anti-insulin trimolecular complex in type 1 diabetes. | Michels AW et al. | โ | 2010 | โ |
| The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. | Alcina A et al. | โ | 2010 | โ |
| The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. | Yoshida K et al. | โ | 2010 | โ |
| The genetics of multiple sclerosis: an update 2010. | Hoffjan S et al. | โ | 2010 | โ |
| The impact of phenocopy on the genetic analysis of complex traits. | Lescai F et al. | โ | 2010 | โ |
| The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. | Kim S et al. | โ | 2010 | โ |
| The pursuit of genome-wide association studies: where are we now? | Ku CS et al. | โ | 2010 | โ |
| The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility. | Bahreini SA et al. | โ | 2010 | โ |
| The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. | Thompson SD et al. | โ | 2010 | โ |
| Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies. | Delli AJ et al. | โ | 2010 | โ |
| Uncovering the roles of rare variants in common disease through whole-genome sequencing. | Cirulli ET et al. | โ | 2010 | โ |
| Unravelling the genetic basis of renal diseases; from single gene to multifactorial disorders. | McKnight AJ et al. | โ | 2010 | โ |
| Update on the genetic risk factors for rheumatoid arthritis. | Orozco G et al. | โ | 2010 | โ |
| Using environmental correlations to identify loci underlying local adaptation. | Coop G et al. | โ | 2010 | โ |
| Using the optimal robust receiver operating characteristic (ROC) curve for predictive genetic tests. | Lu Q et al. | โ | 2010 | โ |
| Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies. | Yoo YJ et al. | โ | 2010 | โ |
| Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. | Cordell HJ et al. | โ | 2010 | โ |
| A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes. | Magitta NF et al. | โ | 2009 | โ |
| Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. | Zhang S et al. | โ | 2009 | โ |
| Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments. | Schadt EE et al. | โ | 2009 | โ |
| Advances in Type 1 diabetes therapeutics: immunomodulation and beta-cell salvage. | Waldron-Lynch F et al. | โ | 2009 | โ |
| A generalized family-based association test for dichotomous traits. | Chen WM et al. | โ | 2009 | โ |
| A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. | Soranzo N et al. | โ | 2009 | โ |
| Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. | Fung EY et al. | โ | 2009 | โ |
| Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. | Howson JM et al. | โ | 2009 | โ |
| Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. | Cooper JD et al. | โ | 2009 | โ |
| A network view of disease and compound screening. | Schadt EE et al. | โ | 2009 | โ |
| Approaches in type 1 diabetes research: A status report. | Raha O et al. | โ | 2009 | โ |
| Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. | Kahles H et al. | โ | 2009 | โ |
| Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies. | Qu HQ et al. | โ | 2009 | โ |
| Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families. | Tayo BO et al. | โ | 2009 | โ |
| Association study of the IL18RAP locus in three European populations with coeliac disease. | Koskinen LL et al. | โ | 2009 | โ |
| A systematic meta-analysis of genetic association studies for diabetic retinopathy. | Abhary S et al. | โ | 2009 | โ |
| Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2). | Michels AW et al. | โ | 2009 | โ |
| Autoimmune type 1 diabetes genetic susceptibility encoded by human leukocyte antigen DRB1 and DQB1 genes in Tunisia. | Stayoussef M et al. | โ | 2009 | โ |
| Autoimmunity risk alleles in costimulation pathways. | Maier LM et al. | โ | 2009 | โ |
| Bench-to-bedside review: Association of genetic variation with sepsis. | Sutherland AM et al. | โ | 2009 | โ |
| Bipolar disorder in the Bulgarian Gypsies: genetic heterogeneity in a young founder population. | Kaneva R et al. | โ | 2009 | โ |
| CD226 Gly307Ser association with multiple autoimmune diseases. | Hafler JP et al. | โ | 2009 | โ |
| Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. | Trynka G et al. | โ | 2009 | โ |
| Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. | Nayak RR et al. | โ | 2009 | โ |
| Common and different genetic background for rheumatoid arthritis and coeliac disease. | Coenen MJ et al. | โ | 2009 | โ |
| Common polymorphic transcript variation in human disease. | Fraser HB et al. | โ | 2009 | โ |
| Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. | Carr EJ et al. | โ | 2009 | โ |
| Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. | Delogu LG et al. | โ | 2009 | โ |
| Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. | Carr EJ et al. | โ | 2009 | โ |
| Current status and the future for the genetics of type I diabetes. | Rich SS et al. | โ | 2009 | โ |
| Detecting gene-gene interactions that underlie human diseases. | Cordell HJ | โ | 2009 | โ |
| Detecting shared pathogenesis from the shared genetics of immune-related diseases. | Zhernakova A et al. | โ | 2009 | โ |
| Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus. | Monti P et al. | โ | 2009 | โ |
| Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity. | Regnault B et al. | โ | 2009 | โ |
| Etiopathogenesis of type 1 diabetes mellitus: prognostic factors for the evolution of residual beta cell function. | Dib SA et al. | โ | 2009 | โ |
| [Evolutionary medicine: an introduction. Evolutionary biology, a missing element in medical teaching]. | Swynghedauw B | โ | 2009 | โ |
| Experimental aspects of copy number variant assays at CCL3L1. | Field SF et al. | โ | 2009 | โ |
| Expression profiling of human genetic and protein interaction networks in type 1 diabetes. | Bergholdt R et al. | โ | 2009 | โ |
| Familial association between type 1 diabetes and other autoimmune and related diseases. | Hemminki K et al. | โ | 2009 | โ |
| Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. | Boraska V et al. | โ | 2009 | โ |
| Family-based genome-wide association studies. | Benyamin B et al. | โ | 2009 | โ |
| Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. | Grant SF et al. | โ | 2009 | โ |
| Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. | Cooper JD et al. | โ | 2009 | โ |
| Functional SOCS1 polymorphisms are associated with variation in obesity in whites. | Gylvin T et al. | โ | 2009 | โ |
| Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity. | Barral PM et al. | โ | 2009 | โ |
| Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. | Kawasaki E et al. | โ | 2009 | โ |
| Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. | Araki M et al. | โ | 2009 | โ |
| Genetics and pathogenesis of coeliac disease. | Heap GA et al. | โ | 2009 | โ |
| Genetics and the general physician: insights, applications and future challenges. | Knight JC | โ | 2009 | โ |
| Genetics and visceral leishmaniasis: of mice and man. | Blackwell JM et al. | โ | 2009 | โ |
| Genetics of type 1A diabetes. | Concannon P et al. | โ | 2009 | โ |
| Genetics of type 1 diabetes and autoimmune thyroid disease. | Pearce SH et al. | โ | 2009 | โ |
| Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. | Festen EA et al. | โ | 2009 | โ |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | โ | 2009 | โ |
| Genome-wide association studies for atherosclerotic vascular disease and its risk factors. | Ding K et al. | โ | 2009 | โ |
| Genome-wide association studies in type 1 diabetes. | Grant SF et al. | โ | 2009 | โ |
| Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders. | Hakonarson H et al. | โ | 2009 | โ |
| Genome-wide association studies reach hepatology. | Karlsen TH | โ | 2009 | โ |
| Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. | Barrett JC et al. | โ | 2009 | โ |
| Genome-wide association study identifies eight loci associated with blood pressure. | Newton-Cheh C et al. | โ | 2009 | โ |
| Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. | Concannon P et al. | โ | 2009 | โ |
| Genome-Wide Significance Levels and Weighted Hypothesis Testing. | Roeder K et al. | โ | 2009 | โ |
| Genotyping technologies for genetic research. | Ragoussis J | โ | 2009 | โ |
| Glycosyltransferase B4GALNT1 and type 1 diabetes in Croatian population: clinical investigation. | Boraska V et al. | โ | 2009 | โ |
| High-throughput SNP genotyping: combining tag SNPs and molecular beacons. | Barreiro LB et al. | โ | 2009 | โ |
| Host genetic and epigenetic factors in toxoplasmosis. | Jamieson SE et al. | โ | 2009 | โ |
| Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. | Mangada J et al. | โ | 2009 | โ |
| Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. | Barton A et al. | โ | 2009 | โ |
| Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study. | Williams FM et al. | โ | 2009 | โ |
| IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells. | Liu S et al. | โ | 2009 | โ |
| IL-21: roles in immunopathology and cancer therapy. | Sรธndergaard H et al. | โ | 2009 | โ |
| IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity. | Wang J et al. | โ | 2009 | โ |
| IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. | Maier LM et al. | โ | 2009 | โ |
| IL7RA polymorphisms and chronic inflammatory arthropathies. | O'Doherty C et al. | โ | 2009 | โ |
| Immunogenetic susceptibility to diabetes mellitus in patients with liver disease. | Montano-Loza AJ et al. | โ | 2009 | โ |
| Immunology of Addison's disease and premature ovarian failure. | Husebye ES et al. | โ | 2009 | โ |
| Impaired performance of FDR-based strategies in whole-genome association studies when SNPs are excluded prior to the analysis. | Marenne G et al. | โ | 2009 | โ |
| Integrative genomics and drug development. | Lum PY et al. | โ | 2009 | โ |
| Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population. | Wu X et al. | โ | 2009 | โ |
| Joint analysis of tightly linked SNPs in screening step of genome-wide association studies leads to increased power. | Becker T et al. | โ | 2009 | โ |
| Localization of Type 1 Diabetes susceptibility in the ancestral haplotype 18.2 by high density SNP mapping. | Santiago JL et al. | โ | 2009 | โ |
| Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. | McGuire HM et al. | โ | 2009 | โ |
| Mapping complex disease traits with global gene expression. | Cookson W et al. | โ | 2009 | โ |
| Meta-analysis of genome-wide linkage studies across autoimmune diseases. | Forabosco P et al. | โ | 2009 | โ |
| MHC fine mapping of human type 1 diabetes using the T1DGC data. | He C et al. | โ | 2009 | โ |
| Microchimerism in type 1 diabetes. | vanZyl B et al. | โ | 2009 | โ |
| Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses. | Nelson P et al. | โ | 2009 | โ |
| Monogenic autoimmune diseases: insights into self-tolerance. | Su MA et al. | โ | 2009 | โ |
| Multilocus Bayesian meta-analysis of gene-disease associations. | Newcombe PJ et al. | โ | 2009 | โ |
| Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. | Ganesh SK et al. | โ | 2009 | โ |
| Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population. | Fedetz M et al. | โ | 2009 | โ |
| Multiple testing in genome-wide association studies via hidden Markov models. | Wei Z et al. | โ | 2009 | โ |
| Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease. | Dobrin R et al. | โ | 2009 | โ |
| New insights into the pathogenesis and genetics of psoriatic arthritis. | Nograles KE et al. | โ | 2009 | โ |
| Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients. | Wieczorek S et al. | โ | 2009 | โ |
| Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease. | Mรกrquez A et al. | โ | 2009 | โ |
| On the level: IRGM gene function is all about expression. | Huett A et al. | โ | 2009 | โ |
| Overview of the Type I Diabetes Genetics Consortium. | Rich SS et al. | โ | 2009 | โ |
| Pathogenesis of primary adrenal insufficiency. | Husebye E et al. | โ | 2009 | โ |
| Pharmacogenetics and functional genomics in asthma. | Sleiman PM et al. | โ | 2009 | โ |
| Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. | Brรผck P et al. | โ | 2009 | โ |
| Population-based genomewide genetic analysis of common clinical chemistry analytes. | Chasman DI et al. | โ | 2009 | โ |
| Predicting Type 1 Diabetes Candidate Genes using Human Protein-Protein Interaction Networks. | Gao S et al. | โ | 2009 | โ |
| Prediction of candidate primary immunodeficiency disease genes using a support vector machine learning approach. | Keerthikumar S et al. | โ | 2009 | โ |
| Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. | Chang MH et al. | โ | 2009 | โ |
| Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. | Hirschfield GM et al. | โ | 2009 | โ |
| PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. | Moore F et al. | โ | 2009 | โ |
| Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. | Nejentsev S et al. | โ | 2009 | โ |
| Reassessment of the type I diabetes association of the OAS1 locus. | Qu HQ et al. | โ | 2009 | โ |
| Recent advances in the genetics of autoimmune disease. | Gregersen PK et al. | โ | 2009 | โ |
| Recent progress in rheumatoid arthritis genetics: one step towards improved patient care. | Plenge RM | โ | 2009 | โ |
| Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. | Liu Y et al. | โ | 2009 | โ |
| Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data. | Deshmukh H et al. | โ | 2009 | โ |
| Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex. | Viken MK et al. | โ | 2009 | โ |
| Rheumatoid arthritis: a view of the current genetic landscape. | Coenen MJ et al. | โ | 2009 | โ |
| Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. | Lin X et al. | โ | 2009 | โ |
| Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. | Gudbjartsson DF et al. | โ | 2009 | โ |
| Shared susceptibility variations in autoimmune diseases: a brief perspective on common issues. | Seldin MF et al. | โ | 2009 | โ |
| Signals of recent positive selection in a worldwide sample of human populations. | Pickrell JK et al. | โ | 2009 | โ |
| Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. | Browning BL et al. | โ | 2009 | โ |
| Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. | Romanos J et al. | โ | 2009 | โ |
| Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. | Burton PR et al. | โ | 2009 | โ |
| Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients. | Mรกrquez A et al. | โ | 2009 | โ |
| Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis. | Liao KP et al. | โ | 2009 | โ |
| Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. | Plagnol V et al. | โ | 2009 | โ |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. | Little J et al. | โ | 2009 | โ |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. | Little J et al. | โ | 2009 | โ |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | โ | 2009 | โ |
| STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. | Little J et al. | โ | 2009 | โ |
| STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | โ | 2009 | โ |
| STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement. | Little J et al. | โ | 2009 | โ |
| STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. | Little J et al. | โ | 2009 | โ |
| Sudden cardiac death: The larger problem... The larger genome. | Spooner PM | โ | 2009 | โ |
| Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease'. Recent advances in genetic understanding of coeliac disease. | Feighery CF et al. | โ | 2009 | โ |
| Systems medicine: the future of medical genomics and healthcare. | Auffray C et al. | โ | 2009 | โ |
| Taking a daily vitamin to prevent type 1 diabetes? | Wasserfall C et al. | โ | 2009 | โ |
| T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. | Esensten JH et al. | โ | 2009 | โ |
| T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. | Doody KM et al. | โ | 2009 | โ |
| Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study. | Teixeira VH et al. | โ | 2009 | โ |
| The CD226 gene in susceptibility of type 1 diabetes. | Douroudis K et al. | โ | 2009 | โ |
| The expanding genetic overlap between multiple sclerosis and type I diabetes. | International Multiple Sclerosis Genetics Consortium (IMSGC) | โ | 2009 | โ |
| The functional annotation of mammalian genomes: the challenge of phenotyping. | Brown SD et al. | โ | 2009 | โ |
| The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders. | Levitt P et al. | โ | 2009 | โ |
| The genetics of autoimmune diseases: a networked perspective. | Baranzini SE | โ | 2009 | โ |
| The genetics of human autoimmune disease. | Invernizzi P et al. | โ | 2009 | โ |
| The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. | Preisig M et al. | โ | 2009 | โ |
| The role of geography in human adaptation. | Coop G et al. | โ | 2009 | โ |
| The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease. | Penna-Martinez M et al. | โ | 2009 | โ |
| The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome. | Julier C et al. | โ | 2009 | โ |
| Type 1 diabetes genes in rats: few or many? | Leiter EH | โ | 2009 | โ |
| Type 1 diabetes in the BB rat: a polygenic disease. | Wallis RH et al. | โ | 2009 | โ |
| [Type 1 diabetes mellitus and celiac disease: family secrets]. | Arregui MV et al. | โ | 2009 | โ |
| Type 1 diabetes mellitus and multiple sclerosis: common etiological features. | Handel AE et al. | โ | 2009 | โ |
| Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiency. | Merriman TR | โ | 2009 | โ |
| Unbiased estimation of odds ratios: combining genomewide association scans with replication studies. | Bowden J et al. | โ | 2009 | โ |
| Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. | Prahalad S et al. | โ | 2009 | โ |
| Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. | Zoledziewska M et al. | โ | 2009 | โ |
| Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. | Blankenhorn EP et al. | โ | 2009 | โ |
| Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. | Saris CG et al. | โ | 2009 | โ |
| A genetic link between type 2 diabetes and prostate cancer. | Frayling TM et al. | โ | 2008 | โ |
| A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. | Concannon P et al. | โ | 2008 | โ |
| Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis. | Fenger M et al. | โ | 2008 | โ |
| Anti-heart autoantibodies in familial dilated cardiomyopathy. | Caforio AL et al. | โ | 2008 | โ |
| Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples. | Hong H et al. | โ | 2008 | โ |
| Autoimmune diseases: insights from genome-wide association studies. | Lettre G et al. | โ | 2008 | โ |
| Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes. | Bortell R et al. | โ | 2008 | โ |
| CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. | Skowera A et al. | โ | 2008 | โ |
| DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. | Gilfillan S et al. | โ | 2008 | โ |
| DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. | Shields BJ et al. | โ | 2008 | โ |
| Exploring case-control genetic association tests using phase diagrams. | Li W et al. | โ | 2008 | โ |
| Family-based samples can play an important role in genetic association studies. | Lange EM et al. | โ | 2008 | โ |
| FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. | Chen R et al. | โ | 2008 | โ |
| Genes and Sjรถgren's syndrome. | Cobb BL et al. | โ | 2008 | โ |
| Genes associated with risk of type 2 diabetes identified by a candidate-wide association scan: as a trickle becomes a flood. | Rich SS et al. | โ | 2008 | โ |
| Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West. | Ikegami H et al. | โ | 2008 | โ |
| Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. | Gieger C et al. | โ | 2008 | โ |
| Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. | Rafiq S et al. | โ | 2008 | โ |
| Genome-wide association scan in psoriasis: new insights into chronic inflammatory disease. | Schrodi SJ | โ | 2008 | โ |
| Genome-wide association studies: a new window into immune-mediated diseases. | Xavier RJ et al. | โ | 2008 | โ |
| Immunology and genetics of type 1 diabetes. | Morran MP et al. | โ | 2008 | โ |
| Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. | Huber A et al. | โ | 2008 | โ |
| Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes. | Miao F et al. | โ | 2008 | โ |
| Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. | Cooper JD et al. | โ | 2008 | โ |
| Modeling genetic inheritance of copy number variations. | Wang K et al. | โ | 2008 | โ |
| New antigenic targets in type 1 diabetes. | Wenzlau JM et al. | โ | 2008 | โ |
| Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. | Skinningsrud B et al. | โ | 2008 | โ |
| Primer: immunity and autoimmunity. | Pietropaolo M et al. | โ | 2008 | โ |
| Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated. | Caron D et al. | โ | 2008 | โ |
| Regulatory T cells in autoimmune endocrine diseases. | Wong FS et al. | โ | 2008 | โ |
| Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. | Rubio JP et al. | โ | 2008 | โ |
| [Sh2b3/Lnk family adaptor proteins in the regulation of lymphohematopoiesis]. | Takaki S | โ | 2008 | โ |
| Shared and distinct genetic variants in type 1 diabetes and celiac disease. | Smyth DJ et al. | โ | 2008 | โ |
| Shared genetic risk factors for type 1 diabetes and celiac disease. | Plenge RM | โ | 2008 | โ |
| The genetics of SLE: an update in the light of genome-wide association studies. | Rhodes B et al. | โ | 2008 | โ |
| The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. | Dendrou CA et al. | โ | 2008 | โ |
| The new genetics and chronic obstructive pulmonary disease. | Kalsheker N et al. | โ | 2008 | โ |
| The positives, protocols, and perils of genome-wide association. | Neale BM et al. | โ | 2008 | โ |
| The pressure of finding human hypertension genes: new tools, old dilemmas. | Charchar F et al. | โ | 2008 | โ |
| Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. | Weiss KM | โ | 2008 | โ |
| Tissue-specific genetic control of splicing: implications for the study of complex traits. | Heinzen EL et al. | โ | 2008 | โ |
| Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease. | Dubois PC et al. | โ | 2008 | โ |
| Unravelling the association of partial T-cell immunodeficiency and immune dysregulation. | Liston A et al. | โ | 2008 | โ |
| Update in endocrine autoimmunity. | Anderson MS | โ | 2008 | โ |
| WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon. | Zalloua PA et al. | โ | 2008 | โ |