Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
paper
Cited
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- Authors
- Cooper, Jason D; Smyth, Deborah J; Smiles, Adam M; Plagnol, Vincent; Walker, Neil M; Allen, James E; Downes, Kate; Barrett, Jeffrey C; Healy, Barry C; Mychaleckyj, Josyf C; Warram, James H; Todd, John A
- Year
- 2008
- Journal
- Nature genetics
- PMID
- 18978792
- DOI
- 10.1038/ng.249
- PMCID
- PMC2635556
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).
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