Follow-up SNPs in the nsSNP and WTCCC studies were genotyped using TaqMan (Applied Biosystems). All genotyping data were scored twice to minimize error; the second operator was unaware of case-control status or and family structure. Concordance data between the two GWA studies and TaqMan genotyping are shown in Supplementary Table 7. All SNPs genotyped in controls did not significantly deviate from Hardy-Weinberg disequilibrium.
