We also examined whether our analyses supported recent findings from Kranzler et al., who conducted a GWAS of alcohol use disorders defined using International Classification of Disease (ICD) codes derived from the electronic health records of individuals participating in the Million Veterans Project4. In this multi-ancestral sample of 274,424 predominantly male veterans, Kranzler et al identified 18 genome wide significant loci for AUD as well as for the consumption subscale of the Alcohol Use Disorders Identification Testkit (AUDIT-C). Their signal for rs1229984 was also noted in our COGA GWAS. In addition, modest evidence for directional and statistical support was also noted for rs12639940 on chromosome 4 (p=0.03; COGA-EA), and rs2961816 on chromosome 5 (p=0.04; COGA EA+AA).
