potential differences, for 2 of the 5 loci (rs1229984 and rs188227250), meta-analyses across samples yielded more significant associations. In addition, the PRS analyses found that the aggregated effect of variants in regions other than the ADH cluster and the ALDH2 locus significantly contributed to AD liability in these diversely ascertained samples. While the proportion of explained variance is modest, it is consistent with other PRS analyses 90 and supports the generalizability of our findings at a polygenic level.
