The Manually Annotated Targets and Drugs Online Resource (MATADOR)19 database was tested for enrichment for 426 significant genes from the MAGMA analysis. This analysis identified 10 drug annotations with FDR < 0.05 including four drugs that are either estrogen receptor agonists (diethylstilbestrol, Implanon [etonogestril implant]), or anti-estrogens (tamoxifen and raloxifene); in addition to nicotine, cocaine, cyclothiazide, felbamate, and riluzole.
