We performed transcriptome-wide association study using MetaXcan for 13 brain tissues and whole blood using GTEx v8. The MetaXcan framework consists of two prediction models for GTEx v8; elastic net and MASHR-based model for deriving eQTL values. The MASHR model is biologically informed, with Deterministic Approximation of Posteriors (DAP-G) based fine mapped variables and recommended by the developers.45 Since the eQTL effect is shared across several tissues, the joint effect of eQTL in 14 tissues was tested using the S-MultiXcan, developed under the MetaXcan toolkit.15 We applied Bonferroni correction (corrected p-value threshold = 1.79×10−7) for all gene-tissue pair tested.
