Each of the risk loci, determined from FUMA (default LD = 0.6), were fine-mapped using CAVIAR.46 The set of causal SNPs were annotated with CADD16 scores followed by positional gene mapping within ±100kb. The genes that overlapped with significant gene cross-tissue eQTL analysis were further tested for colocalization. Coloc17 was used to test colocalization between specific gene eQTL tissue pairs (GTEx v8). The LocusCompareR R package was used to generate regional plots of tissue-specific eQTL and GWAS p-values.
