We used LD Score Regression (LDSC) [12] to estimate SNP-based h2 in the different datasests and the meta-analyses (Figure 3). Because of the unbalanced case/control ratio, we used effective sample size instead of actual sample size in MVP (following the PGC AD GWAS [2]). The h2 of PAU (the meta result) was 0.068 (se = 0.004). The h2 of AUD in the MVP metaanalysis (phases 1 and 2) was 0.095 (se = 0.006) and 0.094 (se = 0.005) in the meta-analysis that combined MVP and PGC.
