Examination of the 66 associated genes for known drug-gene interactions through the Drug Gene Interaction Database v3.0.2 [11] showed 327 interactions between 16 genes and 325 drugs (Supplementary Table 5). Of these 16 genes with interactions, DRD2 had the most drug interactions (n = 177), followed by BDNF (n = 68) and PDE4B (n = 36).