The bioinformatics analyses (Tables 3–5) suggested that different biological systems were being altered by adolescent binge-like drinking within each region. GO analyses (Table 3) indicated that expression of genes involved in neuron projection morphogenesis and positive regulation of cellular component organization was significantly altered by ethanol drinking in the CeA, suggesting that adolescent binge drinking may be altering neuronal function within this region. KEGG analyses (Table 3) indicated that adolescent drinking produced changes in expression of genes involved in neuroactive ligand-receptor interaction, suggesting that ethanol may be altering synaptic transmission within both regions. In addition, KEGG analyses indicated significant changes in expression of genes involved in ErbB and Wnt signaling pathways (Table 3). Wnt pathways are involved in multiple intracellular signaling cascades that promote neuronal survival (Kikuchi et al., 2011; Scott & Brann 2013). The ErbBs are a family of receptor tyrosine kinases that allow cells to interact with the extracellular environment and transducer signals to the nucleus for proper cellular morphogenesis and function (Wadugu and Kuhn 2012; Sanchez-Soria and Camenisch 2010). These results suggest that adolescent binge-like drinking by
