To estimate the potential causal relationship between psychotic disorders and cannabis phenotypes, we used MR (Supplementary Methods). We used the R package TwoSampleMR34 and reported results for three methods (i) inverse variance weighted [IVW],35 (ii) weighted median,36 and (iii) MR Egger.37 We also used MR Pleiotropy Residual Sum and Outlier (MR-PRESSO)38 and Causal Analysis Using Summary Effect estimates (CAUSE).39 Latent Causal Variable (LCV)40 analysis was also applied. The Benjamini-Hochberg correction (q<0.05) was applied across all MR analyses.
