In the WTCCC study, cis mQTLs comprised 14% of the most significant associations (p < 0.001). We asked whether a similar level of cis mQTL enrichment could be observed among the top SNPs in the GAIN and TGen studies of Bipolar Disorder 11, 12. At the given association threshold, a similar percentage, 14.4%, of the top SNPs from the GAIN study were found to be cis mQTLs. Consistent with this trend, the top variants from the TGen study show a significant overlap with local mQTLs (20%). Furthermore, as in the WTCCC study, we observed no enrichment of trans mQTLs (enrichment p > 0.50) among the susceptibility variants from either the GAIN or TGen study.
