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Chunk #24 — 2. Methods — 2.7. SNP Selection, DNA Isolation, and Genotyping — 2.7.1. SNP Quality Control

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Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300.
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SNP genotyping quality control involved ongoing monitoring of SNP signals provided by Qiagen software. Output is provided using three categories for each SNP: pass, fail and check. Data analysis was performed for only those signals meeting the “pass” criterion. Signals that failed or were returned as needing further checking were rerun. If after 3 attempts the SNP did not meet the “pass” criterion, it was eliminated from the analysis and another SNP chosen as a replacement.