In addition, the magnitude of elevation in the polygenic risk scores (risk score elevation) between transmitted risk alleles and untransmitted non-risk alleles in the OCD trios was calculated using risk alleles from the different OCD discovery samples and compared (Figure 3, inset). The risk score elevation in the OCD trios was highest when the primary “OCD - TS/CT” discovery sample was used to derive the risk score compared either to the “All OCD” sample or the combined TS/OCD sample (paired t-test; p=0.022 and p=0.010, respectively), consistent with a dilution of risk when either OCD cases with TS/CT or TS cases without OCD were incorporated in the discovery sample.
