Illumina libraries indicated as 'low-input Fisher et al.' were prepared following the protocol described by Fisher et al. [31] with the following modifications: genomic DNA input into shearing was reduced from 3 µg to 100 ng in 50 µl volume. In addition, for adapter ligation, Illumina paired-end adapters were replaced with palindromic forked adapters with unique 8-base index sequences embedded within the adapter.
