2017, 2012; Oni et al., 2016) because it will allow studies to mitigate an individual’s genetic and/or epigenetic complexity. These benefits include: 1) Reprogramming technology provides a tool to assay functional effects on human neural tissue of alleles that have been previously found to be associated with a risk of alcohol dependence. 2) iPS cell derived neural cells can provide a model to compare differences between individuals, specifically allowing variations in molecular and physiological responses to both acute and chronic alcohol exposure to be studied. 3) Gene function can be studied with regard to genetic variation between individuals. And finally, 4) this will allow studies to investigate how differing effects of alcohol exposure can be observed in at-risk subjects.
