of medial prefrontal cortex including rostral ACC and medial OFC). Although using a small (n=14) and a heterogeneous subject group (i.e., both methadone maintained and abstinent users), these results suggest enhanced connectivity within reward and motivation circuits that may be interpreted in the perspective of altered incentive salience for drugs and drug-associated stimuli (Berridge and Robinson, 1998). Similarly, Wilcox and colleagues (2011) observed increased rsFC between ventral striatum and ventromedial PFC (vmPFC) regions in abstinent cocaine-users.
