In order to estimate whether individuals at the extreme end of the PRS distribution were at elevated risk of AUD, we compared the risk of AUD between those above and below a given threshold in the distribution. We divided these PRSs at the 80th, 90th, and 95th percentile in each sample and estimated the odds ratio (OR) for AUD in the top portion of the distribution relative to the bottom portion of the distribution (e.g., splitting at the 80th percentile compares the top 20% to the bottom 80%). Table 2 provides the estimates for all of those models. Across each threshold for AUD severity in COGA, we observed a similar pattern where, as expected, those in the upper end of the polygenic distribution had greater odds of meeting criteria for AUD. However, regardless of the threshold, the OR’s at each threshold were roughly equivalent. For example, in the case of severe AUD, when dividing 80th percentile (OR = 1.98; 95% CI = 1.53, 2.57), 90th percentile (OR = 2.02; 95% CI = 1.73, 2.36), or 95th percentile (OR = 1.96;
