Finally, we assessed the sensitivity/specificity of these combined PRS by calculating the AUC from receiver operating characteristic (ROC) curves, presented in Fig. 2. AUC from the full model (including both continuous PRS and covariates) for each level of AUD severity ranged from 0.67 to 0.74 in COGA and from 0.65 to 0.76 in FT12. Comparing the AUC for the models with and without PRSs, including the PRS only provided a slight increase in AUC.
