Next, we determined whether each of these PRS contributed to AUD criteria in a model containing all three, simultaneously. Figure 1 presents the parameter estimates for the independent and conditional effect of each PRS in both COGA and FT12. In the conditional model for COGA, each of the PRSs remains significantly associated with AUD criteria, though the associations are attenuated (conditional model ΔR2 = 0.025). In FT12, the PRS for RISK PC and GSCAN DPW remain significant in the conditional model, while the association for PROB ALC PRS is no longer significant (conditional model ΔR2 = 0.035). We averaged the three PRS into one composite PRS score in COGA and averaged the RISK PC and GSCAN DPW PRS in FT12 to carry forward in the following analyses.
