Across each sample and PRS, we observed significant associations between PRS and AUD criteria, even after correcting for a false discovery rate (FDR)30 of 5%. In COGA the GSCAN DPW PRS was most strongly associated with AUD criteria (ΔR2 = 0.017), followed closely by the RISK PC PRS (ΔR2 = 0.016), and lastly the PROB ALC PRS (ΔR2 = 0.012). We see a similar pattern in FT12, where the GSCAN DPW PRS was the strongest association (ΔR2 = 0.030), the RISK PC PRS was slightly weaker (ΔR2 = 0.023), and the PROB ALC PRS performed the worst (ΔR2 = 0.001).
