The frequency of the risk ADH1C 350Val allele varied widely across different populations, based on all the samples: low in the Asian control populations 8% (0% – 20%) and patients 14% (0% – 32%); higher in the European controls 45% (24% – 59%) and patients 45% (30% – 62%); between Asian and European frequencies in the Mexican controls 35% (34% – 38%) and patients 35% (32% – 39%); and less frequent in African controls 13% (12% – 13%) and patients 16% (13% – 17%). Among the 30 Asian studies, 26 studies showed higher 350Val frequency in cases than in controls and one showed no significant difference; among the 17 European studies 10 studies showed higher frequency and two showed equal frequencies; two of three studies of Mexican Americans showed higher frequency; and all the studies of African Americans showed higher frequency in cases than in controls (Table 2).
