For connections showing significant group differences, we performed a one-way ANOVA to evaluate whether any connectivity abnormalities in those with acute MDD were also evident in individuals in remission. Furthermore, we examined correlations between these connectivity indices and depression severity and illness course. Finally, at the suggestion of a reviewer, follow-up analyses were conducted to determine the extent to which putative group differences generalized to within-DMN and DMN-FPN connectivity more broadly by comparing the MDD and HC groups in their mean connectivity of all within-network or between-network pairs. Results from these analyses were generally consistent with those reported in the main text and are presented in full in the Supplement.
