The results described above highlight gene associations that attain genome-wide significance. Additionally, we tested for enrichment of reported disease genes among our PrediXcan results using less stringent significance thresholds. Reported genes were derived from the comprehensive NHGRI catalog of disease-associated variants identified using GWAS25. Five of the seven diseases (bipolar disorder (BD), coronary artery disease (CAD), CD, RA, T1D) had a significant enrichment of reported genes in the PrediXcan results (Figure 6C, Supplemental Figure 7). Results for other p-value thresholds were similar (results not shown). These enrichment analyses on the PrediXcan findings suggest that among the genes that fail to meet strict genome-wide significance, there are likely to be true disease associations.
