In addition to the results described above for autoimmune diseases, we identified two potentially novel disease-associated genes. Lower predicted expression of KCNN4 was associated with an increased risk of hypertension (p-value = 2.62 × 10−6, Table 1) and high predicted PTPRE expression was associated with increased risk of bipolar disorder (p-value = 7.71 × 10−7, Table 1). Interestingly, an intronic SNP in PTPRE was previously found to associate with response to the stimulant amphetamine29,30. In contrast to the original WTCCC single-variant analyses22, the PrediXcan analysis for bipolar disorder and hypertension produced genome-wide significant results. Additional studies of these genes are warranted.
