To our knowledge there are 3 manuscripts that have examined functional connectivity in youth with and without familial AUD. Wetherill et al., 2012 used seed voxel analyses and found FHP youth (aged 12-14) demonstrated relatively less functional connectivity between frontal and parietal regions during a visual working memory (VWM) task (27). Herting et al., 2011 also used seed voxel analyses and demonstrated reduced fronto-cellebellar connectivity within FHP youth (aged 11-15) during rest (28). Finally Weliand et al., 2013 used psychophysiological interaction analyses and found increased nucleus accumbens connectivity with posterior parietal and sensorimotor areas during incentive anticipation in FHP youth (aged 18-22 years; some with prior substance use disorders (SUD))(29). Because of different task demands, regions of interest, analytic approaches (e.g., multivariate vs. univariate), dissimilar age groups, and presence of SUD, it is difficult to draw conclusions from this literature. Interestingly, the most comparable study by Wetherill et al., 2011 found decreased connectivity between bilateral frontal and parietal regions during VWM in FHP youth while we found increased connectivity between similar regions during SWM. One potential reason for this divergence
