Spit for Science (S4S) is a longitudinal study of college students enrolled in a large, urban university in the Mid-Atlantic region of the United States, as previously described (Dick et al., 2014). Briefly, all incoming students age 18 or older were invited to complete surveys with content related to alcohol use and related behavioral and emotional health outcomes in the fall of their first semester. Study data were collected and managed using REDCap electronic data capture tools (Harris et al., 2009). Participants who completed the phenotypic assessments were eligible to provide a DNA sample. The current study includes three cohorts, which matriculated in fall 2011 (n = 2,714), 2012 (n = 2,486), and 2013 (n = 2,403), for a total n = 7,603. Of these, 98% provided a DNA sample. The average (±SD) age was 18.59 (±0.61), and 61% of the sample was female. Self-report race/ethnicity for the sample was 15% Asian, 20% African American, 7% Hispanic, 6% more than 1 race, and 50% White, which closely maps onto overall university demographics (Dick et al., 2014).
