In both groups, the DW paradigm activated a bilateral network that included the prefrontal cortex (PFC) [caudal dorsal anterior cingulate Brodmann area (BA) 32, inferior (BA 47), and middle (MFG; BA 9) frontal gyri], inferior (BA 40) and superior (BA 7) parietal cortices, thalamus, dorsal striatum, midbrain, and cerebellum and deactivated the parahippocampal (BA 30) and rostral anterior cingulate (rACC, BA 32) gyri, precuneus (BA 31), amygdala, and insula (BA 13) (p corr <0.001, cluster-level corrected for multiple comparisons; Fig. 4 and Table 2). Group comparisons showed that activation was higher for controls than for cocaine abusers in the dorsolateral PFC (MFG BA 9, and precentral gyrus BA 6), cerebellum, thalamus, and left caudate (p corr <0.05; Fig. 5A and Table 2); cocaine abusers deactivated more the rACC than controls (p corr <0.05; Fig. 5A and Table 2). There were no statistically significant word-related differences (“Drug” > “Neutral” or “Neutral” > “Drug”) on brain activation. There were no statistically significant word × group interaction effects on brain activation.
