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Chunk #25 — Methods

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Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics.
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As done in the original paper, we ran gene-property analyses on the EXT-minus-23andMe summary statistics to (1) test 54 tissue-specific gene expression profiles, and (2) test gene expression profiles across 11 brain tissues and developmental stages with reference data from BrainSpan (Allen Institute for Brain Science 2022). We used the default settings of SNP2GENE, which match those used to conduct the gene-based analyses reported in the original study (Tables S3, 4).5.How similar is the pattern of genetic correlations with other traits when using down-sampled GWASs?