We used a Bonferroni threshold accounting for all the gene-tissue pairs that were tested (0.05/total number of gene-tissue pairs ≈2.5e-7). This approach is conservative because the correlation between tissues would make the total number of independent tests smaller than the total number of gene-tissue pairs. Height had the largest number of significantly associated unique genes at 1686 (based on a GWAMA of 250 K individuals). Other polygenic diseases with a large number of associations include schizophrenia with 305 unique significant genes (n = 150 K individuals), low-density lipoprotein cholesterol (LDL-C) levels with 296 unique significant genes (n = 188 K), other lipid levels, glycemic traits, and immune/inflammatory disorders such as rheumatoid arthritis and inflammatory bowel disease. For other psychiatric phenotypes, a much smaller number of significant associations was found, with eight significant genes for bipolar disorder (n = 16,731) and one for major depressive disorder (n = 18,759), probably due to smaller sample sizes, but also smaller effect sizes.
