All other GWS results were observed in the AA part of the sample. This included two distinct chromosome 8 regions, one region under the ordinal model and one under the adjusted ordinal model. Several closely mapped SNPs at the DLC1 (deleted in liver cancer 1) locus yielded p values just under 5 × 10−8, the most significant being rs289519 (MAF = .23) under the ordinal model (regional Manhattan plot; Figure 3B). More than six megabases distal to DLC1, numerous tightly mapped markers in an intergenic region showed GWS under the adjusted ordinal model, with rs6996964 being the most significant at p = 1.1 × 10−9. This region is flanked by CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1) and INTS10 (integrator complex subunit 10) (regional Manhattan plot; Figure 3C).
