There were numerous associations at a region on chromosome 14 from 45,307,535 to 45,613,093 base pairs (rs146754986 to rs145624594), spanning >300,000 base pairs (regional Manhattan plot; Figure 3D). The region includes seven named loci: C14orf28, KLHL28 (kelch-like family member 28), FAM179B (family with sequence similarity 179, member B), PRPF39 (pre-mRNA processing factor 39), SNORD127 (small nucleolar RNA, C/D box 127), FKBP3 (FK506 binding protein 3, 25kDa), and FANCM (Fanconi anemia, complementation group M). Although support came from both the Yale-Penn and SAGE samples, it was generally greater in the former. GWS p values were as low as 4.73 × 10−10.
