Chunk #16 — Methods — Subjects and samples — Translating ribosome affinity purification (TRAP)-seq mice

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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All animal procedures were performed in accordance with the guidelines of Washington University’s Institutional Animal Care and Use Committee. The Rosa26fsTRAP mice (Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp) [43] (The Jackson Laboratory) were crossed with PVCre mice (Pvalbtm1(cre)Arbr) [44] (The Jackson Laboratory) to produce PV-TRAP mice directing expression of EGFP-L10a ribosomal fusion protein in parvalbumin (PV) expressing cells.