The correlations between the PRS and rs1229984 ranged from −0.15 to −0.05. As shown in Table 3, the variance predicted by the PRS was partially independent of the inclusion of rs1229984 in ADH1B. There was a significant association between rs1229984 genotype and alcohol use, DSM4AD, DSM5AUDSX, MAXD, and SRE-T with rs1229984 predicting 0.34 – 1.19% of the variance in these drinking measures. After including rs1229984 genotype as a covariate, the alcohol consumption PRS continued to predict 0.14 – 1.22% of the variance across the drinking measures. In particular, rs1229984 genotype had the least influence on alcohol use, for which the PRS predicted more variance than the ADH1B genotype (Δmarginal R2 for ADH1B conditional on PRS=0.49%; Δmarginal R2 for PRS conditional on ADH1B=1.22%).
