Within the survival analysis framework, alcohol consumption PRS (pT < 0.01) were associated with a 1.11 [95% C.I. 1.06 – 1.16, p = 2.08e-5] hazards of onset of DSM4AD, even after adjustment for covariates. There was no evidence for violation of the proportional hazards assumption. As shown in Figure 1 (Panel A), individuals with scores in the lowest quartile were least likely to have met criteria for DSM4AD, with survival probabilities being higher particularly in those aged 35 and older. Adjustment for rs1229984, which was strongly associated with decreased risk of onset of DSM4AD [Hazards Ratio (HR) = 0.48, 95% C.I. = 0.37 – 0.63, p = 7.85e-08], had little influence on the effect of the overall PRS [HR = 1.09, 95% C.I. = 1.04 −1.14, p = 2.86e-4].
