As expected, sex was strongly associated with all aspects of problem drinking, including DSM-4AD and DSM5AUDSX (p < 2e-16; higher likelihood of problem drinking in males). Family history was positively associated with all drinking measures except for alcohol use. Age at last interview was associated with DSM-4AD, DSM5AUDSX, and the reduction/cessation comparison of those with no lifetime AUD (Group A) vs. those with lifetime AUD and current symptoms or no symptoms but high-risk drinking (Group B), even after accounting for birth cohort effects. Mean PRS scores did not differ as a function of sex, age, or family history (p > 0.1). Interactions between the PRS and sex, age at final interview and family history were non-significant (p > 0.05), suggesting uniformity of effect sizes across these groups (Table 4).
