Genomic control lambda parameters35 estimated from the meta-analysis of 1 252 222 autosomal SNPs indicated minimal inflation of test statistics over the null value of 1.0; HA: 1.01, NS: 1.04, RD: 1.00, P: 1.02 (Figure 1 QQ plots). No SNPs were significant at a genome-wide threshold of 5 × 10−8. The most significant finding was for rs17608059 on chromosome 17 with scale P, with a P-value of 2.8 × 10−7 (Table 2). There were 83 SNPs from 16 independent genomic locations on 12 chromosomes with P<10−5 (HA: 9 SNPs, NS: 57 SNPs, RD: 10 SNPs, P: 7 SNPs, Supplemental Table S1). Scales HA and RD were also analyzed separately by sex; across all four analyses 73 SNPs from 13 independent genomic locations resulted in P<10−5 but none were significant at a genome-wide level (Supplemental Table S2). Meta-analysis of the three Finnish cohorts alone also did not produce any genome-wide significant results (data not shown), nor did meta-analysis including the heterogeneity option. A priori, both QIMR and HBCS might be considered to be cohorts with a heterogeneous signal; QIMR due to
