Finnish cohorts alone also did not produce any genome-wide significant results (data not shown), nor did meta-analysis including the heterogeneity option. A priori, both QIMR and HBCS might be considered to be cohorts with a heterogeneous signal; QIMR due to population differences and HBCS due to age differences. Among the handful of markers with METAL heterogeneity P<10−5 for one or more scales, it was never true that only the QIMR sample or the HBCS sample had a test result considered to be heterogeneous from the other three cohorts.
