de Moor et al.15 found two SNPs on 5q14.3 to be genome-wide significantly associated with openness to experience (rs1477268 and rs2032794) and one SNP on 18q21.1 to be genome-wide significantly associated with conscientiousness (rs2576037). Neither association was replicated in an independent sample. Openness to experience and conscientiousness are not measured in our sample and are only modestly correlated to our phenotypes (correlations of openness to experience/conscientiousness with NS, HA, P and RD are 0.27/–0.36, –0.33/–0.24, 0.03/0.46 and 0.32/0.07, respectively6); however, we still reviewed the association findings for these three SNPs in our results. We find rs1477268 and rs2032794 to be associated to NS (P=0.03). In de Moor et al.,15 the ‘T' allele at these markers resulted in a decrease in openness to experience; we find the ‘T' allele to result in a decrease in NS. Association of HA, RD and P to these two SNPs all resulted in P>0.30. de Moor et al.15 found the ‘T' allele of rs2576037 to result in a decrease in conscientiousness. In our sample the ‘T' allele was associated with a decrease in HA (P=0.10) and P (P=0.076). Association of RD and NS to rs2576047 both resulted in P>0.27.
