In the field of human psychopharmacology, alcohol challenge studies in particular stand to benefit from direct replication attempts, as laboratory studies measuring acute alcohol response traditionally suffer from a number of methodological issues that limit impact and generalizability. For example, such studies often have a small sample size, consist of heterogeneous samples, and use alcohol administration routes and dependent measures that may not be psychometrically sound and can often be quite disparate across studies. As observed in other fields (Ioannidis, 2005; Schmidt, 2009), most alcohol challenge studies have focused on conceptual replication, i.e., trying to replicate the existence of a concept using different methodologies or sample characteristics (for example, see Corbin et al., 2013; Duranceaux et al., 2008; Schuckit et al., 2004). However, conceptual replication studies can only confirm a prior finding; if they present results that differ from the original study, the failure to replicate is often ascribed to the methodological differences between the studies and as such, may lead to publication bias (Ioannidis, 2005; Nosek et al., 2012; Pashler and Harris, 2012). In contrast, direct replication studies, which
