Three of the 11 RVs genotyped were located in DISC1. Rs139667828 and rs116628628 are 242kb apart, and rs116628628 and rs61737326 are 73kb apart. The three RVs are independent of each other. In this study, we did not have a prior hypothesis of whether the RVs are protective or deleterious, because each mutation can have different functions in terms of gene expression level and protein function.
