After combining all results, the association of rs61835088 with CD TD strengthened (HR = 0.87, P = 3.71 × 10−9, Table 3, Figure 1). For the same outcome, the association with intergenic chromosome 21 SNP rs2825295 in AAs surpassed the GWS threshold in the combined Yale-Penn/COGA meta-analysis (P = 2.19 × 10−8, Table 3, Figure 1). Each minor (T) allele at rs2825295 was associated with 0.43 fewer years between first cocaine use and dependence among those who converted. The top variant in regions with P-values < 1.0 × 10−6 after combining all data are shown in Tables 3 (CD) and 4 (OD in AAs). For OD TD, all but one of the top associations was in the AA portion of the sample. There was one OD TD signal in the combined EA and AA sample, rs8063946 (P = 1.87 × 10−7) in the gene FTO, which for clarity is not shown in Table 4. Near-GWS evidence of association was obtained in the combined samples with SNPs in three other genes previously associated with addiction phenotypes: rs114341823 in GRIN2B [44, 45],
