10−7) in the gene FTO, which for clarity is not shown in Table 4. Near-GWS evidence of association was obtained in the combined samples with SNPs in three other genes previously associated with addiction phenotypes: rs114341823 in GRIN2B [44, 45], which encodes the glutamate ionotropic receptor NMDA type subunit 2B was associated with OD TD in AAs (P = 1.45 × 10−7); the variant in FTO [46-48] described above; and rs73721103, which is between alpha-aminoadipic semialdehyde synthase (AASS) and LOC102724527 but is ~100 kilobases from PTPRZ1 [49, 50], which encodes the protein tyrosine phosphatase receptor type Z1 with CD TD in AAs (P = 2.81 × 10−7).
