Regional plots of the six genomic regions can be found in Supplementary Figs. 4–9. The six leading markers show odds ratios of 1.12–1.33 and no significant heterogeneity across studies (Table 3). This is supported by PM-plots (posterior probability that a SNP effect exists in a given study) showing a high consistency of effects among the studies predicted to have an effect13 (Supplementary Figs. 10–15). A z-test on the effect sizes confirmed similar effects for men and women for the three leading variants in the joint-sex analyses, and significant sex-specificity for the three male hits identified in the sex-stratified analyses (Supplementary Table 4).
