We used partitioned LD score 47,74 and DEPICT 47 regression to evaluate which somatic tissues and brain tissues were enriched in the BD GWAS. We used summary-data-based Mendelian randomization (SMR) 48,50 to identify SNPs with strong evidence of causality of brain or blood gene expression or methylation in BD risk (Supplementary Table 16), with a test for heterogeneity to exclude regions with LD between distinct causal SNPs (pHET < 0.01).
