top genes in the Wolstenholme et al [10] study. FOS, a main hub gene in our pathway analysis, was also changed in the Bell et al. [6] data and two other genes in our pathway, PDYN and DRD1, were changed in the Contet et al. [66] study. B2M was changed by LPS treatment in the present study, was one of the top genes in Mulligan et al. [13] and was also changed in the Melendez et al. [67] study of chronic intermittent ethanol exposure in mice. This gene is related to inflammatory processes and is changed in astrocytes in response to LPS exposure [68]. Notably, deletion of B2M in mice reduces alcohol consumption [26]. Of the 137 genes from the present study listed in Table S4, 48 were differentially expressed in the Ponomarev et al. [11] study of prefrontal cortex of human alcoholics and 25 were changed in the Liu et al. [3] data.
